Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

By H. Ishigame, S. Kakuta, T. Nagai, Motohiko Kadoki, Aya Nambu, Yutaka Komiyama, N. Fujikado, Yuko Tanahashi, A. Akitsu, Hayato Kotaki and 4 more. Immunity, 2009

1,087 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/b55fdff343463b4ad3f8bb39a87381825162b9f6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. D. Cua
2. Y. Iwakura
3. H. Ishigame
4. J. Kolls

In Immunology

1. TA Wynn
2. D. Cua
3. S. Gaffen
4. C. Tato
5. Y. Iwakura
6. M. McGeachy
7. J. Kolls
8. M. Wilson

In Pathology and Forensic Medicine

1. D. Cua
2. C. Tato
3. S. Gaffen
4. TA Wynn
5. Y. Iwakura
6. J. Kolls
7. H. Ishigame
8. M. McGeachy

Citations in the corpus

• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “In another possibility, we and others reported that IL-17A and IL-17F is important for the induction of b-defensins in epithelial cells (Ishigame et al., 2009; Kao et al., 2004).”
• IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. (2010, background): “aureus skin infections (52), and that a large proportion of the resident epidermal γδ T cells constitutively express the retinoid-related orphan receptor–γt (RORγt) transcription factor, which is required for IL-17 production (53).”
• The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities (2012, background): “Infections with this pathogen in mice produce robust immune responses characterized by a mixed Th1/Th17 response (100, 114).”
• Evidence for a cross-talk between human neutrophils and Th17 cells. (2010, background): “Accordingly, a recent study showed that murine CD4 T cells, which express IL-17RA and Act1, but not IL-17RC, secrete CCL2, CCL3, GM-CSF, IL1β and IL-9 in response to IL-17A, but not IL-17F.(50) Finally, it was recently shown that murine”
• Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010, background): “A comprehensive study by Ishigame et al. (2009) highlighted the overlapping but also distinct roles of IL17A and IL17F.”
• Innate IL-17-producing cells: the sentinels of the immune system (2010, background): “Fibroblasts, epithelial cells and endothelial cells express both IL-17RA and IL-17RC, whereas T cells express IL-17RA but not IL-17R”
• The IL-17 family of cytokines in health and disease (2019, background): “IL-17A is implicated more strongly than IL-17F in driving autoimmunity (Ishigame et al., 2009; Veldoen, 2017), although the role of IL-17AF remains unclear and bispecific Abs targeting both isoforms are under consideration for therapy (Torres et al.”
• Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa (2010, positive): “We also assessed the expression of genes encoding colitis-associated cytokines that influence susceptibility to C. rodentium infection, including IL-17A and IL17F [36], IL-22 [37], and IL-23 [38].”