IL-17 family cytokines and the expanding diversity of effector T cell lineages.

By C. Weaver, R. D. Hatton, Paul R. Mangan, L. Harrington. Annual Review of Immunology, 2007

2,001 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/b155e3f120f3e5c65502e0df4710d47f3c6b8227

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Citations in the corpus

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells (2007, background): “that induce the mobilization, recruitment and activation of neutrophils and trigger the production of proinflammatory cytokines and chemokines by a broad range of cellular targets, including epithelial cells, endothelial cells and macrophage”
T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “Th17 differentiation is initiated by TGF-β and either IL-6 or IL-21, which activate signal transduction and activator of transcription (STAT) 3 and induce expression of the transcription factor RORγt, ultimately resulting in lineage specification (56, 57).”
Raising the NKT cell family (2010, background): “IL-17 is typically viewed as a product of T H 17 CD4 + helper T cells, which have a key role in autoimmune pathology in disease models such as experimental autoimmune encephalomyelitis and collagen-induced arthriti”
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, neutral): “Three effector pathways of T cell differentiation are now defined: T H 1 responses promoted by Stat1 and Stat4 signaling, T H 2 responses promoted by Stat6 signaling and T H 17 responses promoted by Stat3 signalin”
Skin immune sentinels in health and disease (2009, background): “In particular, IL-17A and IL-22 , which are produced by T H 17 cell”
Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “In contrast to studies on IL-21, there is a consensus that IL-23 is required in vivo for Th17 cells to mediate inflammatory and protective immune responses (McKenzie et al., 2006; Weaver et al., 2007).”
Functional specialization of interleukin-17 family members. (2011, background): “Five additional structurally related cytokines were recently identified: IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F to form the IL-17 family (Kolls and Lindén, 2004; Weaver et al., 2007) and each additional member of the IL-17 family shares 16%– 50%amino acid identity with IL-17A”
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, background): “Th17 cells produce an unusual set of cytokines, including IL-17A, IL-17F, IL-22, and varying degrees of IFN-g and IL-10 (Chen and O’Shea, 2008; Stockinger and Veldhoen, 2007; Weaver et al., 2007).”
Late Developmental Plasticity in the T Helper 17 Lineage (2009, positive): “Prior to discovery of the Th17 lineage and a nonredundant role for IL-23 in several models of autoimmunity, immune pathogenesis in these models was ascribed to dysregulated Th1 responses (reviewed by McGeachy and Cua, 2008; Weaver et al., 2007).”
C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE (2009, background): “IL-17 can mediate protection against extracellular pathogens by promoting neutrophil recruitment but has also been shown to cause immunopathology in various models of autoimmunit”
Identification of IL-17-producing FOXP3+ regulatory T cells in humans (2009, background): “Although FOXP3 Treg cells are critical for control of autoimmunity and inflammation (34), Th17 cells have been implicated in mediating inflammation and autoimmune diseases (4).”
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. (2008, background): “The CD4+ T cell compart- ment is particularly complex because it includes T helper (Th) 1, Th2, Th17 (Weaver et al., 2007), and follicular helper T (Tfh) cells (King et al., 2008) that arise by polarized differentiation of naive precursors, as well as regulatory T (Treg) cells (Sakaguchi et al.,…”