Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

By Matthew A. Stark, Yuqing Huo, Tracy L. Burcin, M. Morris, T. Olson, Klaus Ley. Immunity, 2005

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Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “” Efferocytosis reduces the production of interleukin (IL)-23 and IL-17 and dampens G-CSF production [9].”
A protective function for interleukin 17A in T cell–mediated intestinal inflammation (2009, neutral): “Notably, at steady state, γδ T cells are the main IL-17-producing lymphocyte subset in mic”
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007, background): “IL-17 induces expression of IL-6 and IL-8, is important for neutrophil infiltration, and is critical for full disease pathogenesis of the highly inflammatory experimental autoimmune encephalomyelitis model (Fossiez et al., 1996; Hofstetter et al., 2005; Komiyama et al., 2006; Stark et al., 2005; Yao”
Neutrophils, from marrow to microbes. (2010, background): “When macrophages and dendritic cells phagocytose apoptotic neutrophils in tissues, their production of interleukin 23 (IL-23) is reduced (Ley et al., 2006; Stark et al., 2005; von Vietinghoff and Ley, 2009).”
Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007, background): “Specific functions for the IL-23 and IL-17A pathway in the homeostatic regulation of granulopoiesi”
Neutrophils and immunity: challenges and opportunities (2006, background): “The release of IL-23 is suppressed when macrophages ingest apoptotic neutrophil”