The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

By Nevan J. Krogan, J. Dover, Adam Wood, J. Schneider, Jonathan Heidt, Marry Ann Boateng, Kimberly M. Dean, Owen W. Ryan, A. Golshani, M. Johnston and 2 more. Molecules and Cells, 2003

778 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad403b16f76a31f6573d89b6cc053727e72cd790

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Citations in the corpus

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. (2005, background): “Rad6 is involved in the histone ubiquitination that is required for methylation by Dot1 and Set1 (Briggs et al., 2002; Krogan et al., 2003a; Ng et al., 2003, 2002; Sun and Allis, 2002; Wood et al., 2003).”
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. (2005, methodology): “This is in contrast to modifications such as trimethylation of lysine 4 of histone H3 in yeast, which does correlate with transcription rate and typically occurs on the first nucleosomes downstream of the transcription initiation site (Bernstein et al., 2002; Krogan et al., 2003a; Ng et al., 2003b).”
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. (2004, background): “Several of the menin point mutants, P12L, L22R, Ser 5 phosphorylated CTD, or unphosphorylated CTD. Menin specifically co-precipitated Rpb1 that is phos-A309P, and W436R, were likewise associated with complexes that methylate histone H3 (Figure 5, upper panel, phorylated on Ser 5 (Figure 6, 2nd panel”
Control of Embryonic Stem Cell State (2011, background): “Based on studies in yeast, the Paf1 complex couples transcription initiation and elongation with histone H3K4 and H3K36 methylation (Krogan et al., 2003).”
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. (2007, background): “Trimethylation of H3K4 has been proposed to link transcription initiation to elongation and mRNA processing (Krogan et al., 2003; Morillon et al., 2005).”
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, background): “The Ctr9 ChIPseq data indicate that the PAF1 complex generally associates with the transcribed portion of most active genes, which is consistent with its proposed roles in elongation, mRNA processing, and chromatin modification (Adelman et al., 2006; Krogan et al., 2003; Pokholok et al., 2002; Zhu e”
H3K4me3 breadth is linked to cell identity and transcriptional consistency (2014, background): “Conversely, PAF1, which associates with elongating Pol II, can recruit methyltransferase complexes responsible for the deposition of both H3K4me3 and H3K79me2 (Krogan et al., 2003), an elongation mark enriched at the broadest H3K4me3 domains.”
The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis (2012, background): “Very little was known about the exact molecular function of the Paf1 complex in transcription until the subunits of this complex appeared as hits in the GPS biochemical screen when exploring for factors required for proper H3K4 and H3K79 methylation (54).”
Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II (2003, background): “These results suggested that the function of Set2 is similar in some way to the functioning of COMPASS and the Set3 complex.”
The role of chromatin during transcription. (2007, background): “PAF also participates in recruiting the histone H3K4 methyltransferase Set1 complex (COMPASS) for elongating Pol II (Krogan et al., 2003a; Ng et al., 2003b; Wood et al., 2003).”
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004, background): “Furthermore, genetic evidence from S. cerevisiae suggests that Dot1, the H3- K79 methylase, may also be recruited to chromatin by the elongating polymerase complex (Krogan et al. 2003a).”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Evidence in budding yeast indicates that H3K4me3 modiﬁcation occurs subsequent to Pol II recruitment and Ser5 phosphorylation of the Pol II C-terminal domain (San-tos-Rosa et al., 2002; Krogan et al., 2003a; Ng et al., 2003; Pokholok et al., 2005).”
Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue (2013, background): “Paf1 belongs to the five-subunit Paf complex that recruits the histone methyltransferase Set1 to transcribed genes (35).”