Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.

By Ryan M. Raisner, Paul D. Hartley, M. Meneghini, M. Bao, C. Liu, Stefan Schreiber, Oliver J. Rando, H. Madhani. Cell, 2005

736 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f5cab0d6045ac6918a0f2a1cd5beb0ea7cf8712

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In Molecular Biology

Citations in the corpus

The role of chromatin during transcription. (2007, background): “High-resolution mapping reveals that two wellpositioned Htz1-containing nucleosomes flank a 200 bp nucleosome-free region (NFR; Raisner et al., 2005).”
Genomic nucleosome organization reconstituted with pure proteins (2016, positive): “These GRFs are implicated in global nucleosome organization in vivo (Badis et al., 2008; Hartley and Madhani, 2009; Kubik et al., 2015; Raisner et al., 2005; Tsankov et al., 2010; van Bakel et al., 2013).”
Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals (2008, background): “The only exception is Reb1, a highly abundant factor that possesses ATPindependent chromatin remodeling activity [ 48 ].”
High-resolution profiling of histone methylations in the human genome. (2007, background): “Z was highly enriched at promoter regions both upstream and downstream of TSS, which is similar with its distribution in yeast (Raisner et al., 2005).”
The biology of chromatin remodeling complexes. (2009, background): “These nucleosomes may be less stable than canonical nucleosomes, facilitating promoter DNA exposure and activation (19, 115).”
Modeling gene expression using chromatin features in various cellular contexts (2012, neutral): “Z, H3K9ac and H3K27ac as promoter marks [5,24], H3K36me3 and H3K79me2 as structural marks [25,26], H3K27me3 and H3K9me3 as repressive marks [6], and H3K4me1, H4K20me1 and H3K9me1 as distal/other marks [4,6].”
Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes (2013, neutral): “The function of the histone variant H2AZ is most clearly deﬁned at promoters where it ﬂanks the nucleosome-free region and has been found to prevent the spread of heterochromatin (Raisner et al., 2005).”
Comprehensive Genome-wide Protein-DNA Interactions Detected at Single Nucleotide Resolution (2011, background): “Reb1 is involved in many aspects of transcriptional regulation by all three yeast RNA polymerases and promotes formation of nucleosome-free regions (NFRs) (Hartley and Madhani, 2009; Raisner et al., 2005).”
Dynamic regulation of nucleosome positioning in the human genome. (2008, neutral): “Z has been reported to decorate two nucleosomes, one upstream and one downstream of TSSs in yeast (Raisner et al., 2005).”
A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. (2008, background): “…of nucleosome locations in Saccharomyces A number of high-resolution genome-wide maps of nucleosome locations in Saccharomyces have recently been experimentally determined (Raisner et al. 2005; Yuan et al. 2005; Albert et al. 2007; Lee et al. 2007; Whitehouse et al. 2007; Shivaswamy et al. 2008).”