Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.

By M. Carrozza, Bing Li, L. Florens, Tamaki Suganuma, S. Swanson, Kenneth K. Lee, Wei-Jong Shia, Scott D. Anderson, John R. Yates III, M. Washburn and 1 more. Cell, 2005

1,386 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1162defd7d73af2e184d6baf1dbc00a1a71b2ab

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In Molecular Biology

1. Yi Zhang
2. A. Bird
3. Yang Shi
4. J. Whetstine
5. A. Shilatifard
6. Keji Zhao
7. Kairong Cui
8. C. D. Allis

Citations in the corpus

• Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “2005; Lee and Shilatifard 2007) and possibly fulfills important roles in suppression of inappropriate transcription within the body of genes (Carrozza et al. 2005), the H3K9me3/me2 mark has generally been associated with transcriptional repression and formation of heterochromatin involving the recru”
• Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, neutral): “Supporting this idea, Carrozza et al. (2005) (this issue of Cell) have found that strains lacking Set2 or Rpd3C(S) display internal initiations in several genes.”
• The RNA polymerase II CTD coordinates transcription and RNA processing. (2012, background): “Rpd3S then transfers to H3 by interaction of the Eaf3 and Rco subunits with methylated H3K36, which is required for activation of acetylation activity (Drouin et al. 2010; Govind et al. 2010).”
• Regulation of nucleosome dynamics by histone modifications (2013, neutral): “This complex contains the chromodomain protein Eaf3, which associates with H3K36me3 in gene bodies 40,41 .”
• How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “In another intriguing case, the Rpd3S complex has two subunits that are required for in vitro interaction with H3K36me and hyperacetylated nucleosomes: the chromodomain of Eaf3p is a modest H3K36me3-binding effecto”
• Gene regulation by the act of long non-coding RNA transcription (2013, background): “Both SET3C and RPD3S are proposed to have a general role in repressing cryptic promoters within gene bodies [61,66] and a genome-wide study implied a role for SET3C in overlapping lncRNA-mediated silencing of a set of pc genes in yeast [66].”
• DNA methylation landscapes: provocative insights from epigenomics (2008, background): “In particular, methylation of histone H3 lysine 9 (H3K9), once thought of as diagnostic of constitutive heterochromatin, is reported to occur within actively transcribed gene”