Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II

By Nevan J. Krogan, Minkyu Kim, A. Tong, A. Golshani, G. Cagney, Veronica Canadien, D. Richards, B. Beattie, Andrew Emili, Charles Boone and 3 more. Molecular and Cellular Biology, 2003

720 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1001bf6de23027491b00bc0222246be0198fb1c2

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In Molecular Biology

1. Richard A. Young
2. D. Reinberg
3. A. Shilatifard
4. Yang Shi
5. J. Whetstine
6. E. Li
7. S. Berger
8. Nevan J. Krogan

Citations in the corpus

• A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Evidence in budding yeast indicates that H3K4me3 modification occurs subsequent to Pol II recruitment and Ser5 phosphorylation of the Pol II C-terminal domain (San-tos-Rosa et al., 2002; Krogan et al., 2003a; Ng et al., 2003; Pokholok et al., 2005).”
• The role of chromatin during transcription. (2007, background): “PAF also participates in recruiting the histone H3K4 methyltransferase Set1 complex (COMPASS) for elongating Pol II (Krogan et al., 2003a; Ng et al., 2003b; Wood et al., 2003).”
• Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, positive): “Methylations are not uniform throughout the genome, and specific modifications have been correlated with transcription activation or repression (Briggs et al., 2001; Krogan et al., 2002a, 2003c; Ng et al., 2002, 2003; van Leeuwen et al., 2002).”
• Elongation by RNA polymerase II: the short and long of it. (2004, background): “Set2 was further demonstrated to directly interact with the CTD of the large subunit of RNAPII, and partial deletion of the CTD, or the CTD-kinase Ctk1 (the yeast homolog of P-TEFb), resulted in a loss of H3K36 methylation (Li et al. 2002, 2003; Krogan et al. 2003c; Xiao et al. 2003).”
• Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. (2003, background): “Methylation of K4 via Set1 occurs during early elongation steps (Krogan et al. 2003a; Ng et al. 2003a), whereas K36 methylation by Set2 occurs during later elongation steps (Krogan et al. 2003b; Schaft et al. 2003).”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “Previous studies linked H3-K36Me2/Me3 to transcriptional elongation (Krogan et al., 2003; Li et al., 2003; Schaft et al., 2003; Xiao et al., 2003).”
• Gene regulation by the act of long non-coding RNA transcription (2013, background): “For example, in yeast the SET1/2 methyltransferases, which induce H3K4me2 and H3K36me3 in the body of transcribed genes, bind and travel with elongating RNAPII [58-60].”
• Phosphorylation and functions of the RNA polymerase II CTD. (2006, background): “Because of the binding specificity of Set2 and because CTDK-I efficiently uses Ser5P repeats to generate Ser2,5P repeats in vitro (Jones et al. 2004), we propose that during elongation the CTD contains repeats phosphorylated at both Ser2 and Ser5 positions.”
• Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. (2005, background): “Rad6 is involved in the histone ubiquitination that is required for methylation by Dot1 and Set1 (Briggs et al., 2002; Krogan et al., 2003a; Ng et al., 2003, 2002; Sun and Allis, 2002; Wood et al., 2003).”
• Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (2006, background): “Importantly, H2BK123ub1 is dependent on PAF Cell 125, 703–717, May 19, 2006 ª2006 Elsevier Inc. 703 (Krogan et al., 2003a; Ng et al., 2003; Wood et al., 2003b).”