Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

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Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. (2013, positive): “To further investigate the relative affinity of proteins for C versus mC versus hmC in a single experiment, we made use of a triple pull-down approach (Vermeulen et al., 2010), in which mESCs are grown in three different SILAC media.”
Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation (2010, methodology): “In order to identify proteins that bind to chromatin in a modification-dependent manner we utilised a SILAC pulldown approach that we have developed to identify interactors of histone modifications (Vermeulen et al., 2010).”
Cancer epigenetics: from mechanism to therapy. (2012, methodology): “The concept of multivalent engagement by chromatin-binding modules has recently been explored by using either modified histone peptides (Vermeulen et al., 2010) or in-vitro-assembled and -modified nucleosomes (Bartke et al., 2010; Ruthenburg et al., 2011).”
The interplay of histone modifications – writers that read (2015, positive): “In this way, positive feedback from the local chromatin structure will also allow robust domains of H3K27me3 to be maintained over repressed genes.”
A double take on bivalent promoters. (2013, background): “Other factors bound by H3K4me3 include the chromatin remodeler CHD1, the SAGA complex, and the H3K9me2-, H3K27me2-, and H4K20me1-specific demethylase PHF8 (Horton et al. 2010; Vermeulen et al. 2010).”