Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

By C. Hughes, O. Rozenblatt-Rosen, T. Milne, T. Copeland, S. Levine, Jeffrey C. Lee, D. Hayes, K. S. Shanmugam, Arindam K Bhattacharjee, C. Biondi and 4 more. Molecules and Cells, 2004

648 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/986c5e800435055b3d4342817df6b327261b1d22

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Citations in the corpus

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription (2013, background): “Previous studies have shown that members of the Mll family of HMTs are able to associate with the C-terminal domain (CTD) of RNAPII, in some cases dependent on phosphorylation of CTD serine 2 (Hughes et al., 2004; Krogan et al., 2003; MacConaill et al., 2006; Milne et al., 2005; Ng et al., 2003; Ran”
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene (2008, background): “, 2003], histone methyltransferase complex [Hughes et al., 2004], and ERa [Dreijerink et al.”
The RNA polymerase II CTD coordinates transcription and RNA processing. (2012, background): “Additionally, association of the mixed lineage leukemia (MLL) Set1-like factors MLL1 and MLL2 with Ser5-P has been reported (Hughes et al. 2004; Milne et al. 2005).”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Similar studies in mammalian cells show that components of H3K4 methyltransferase complexes interact with the Ser5-phosphorylated form of Pol II, indicating that transcription initiation coincides with H3K4me3 deposition (Hughes et al., 2004).”
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (2005, background): “Although WDR5 is common to MLL1 c(Nakamura et al., 2002; Yokoyama et al., 2004), MLL2 M(Hughes et al., 2004), and hSET1/HCF (Wysocka et al., v2003) complexes, the first two steps efficiently separate tMLL1 from hSET1 (mostly in the P11 BC300 and SP MBC300 fractions) and MLL2 (mostly in P11 BC300…”
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. (2005, positive): “Human Set1-like enzymes are present in multiprotein complexes that appear to be structurally and functionally similar to the yeast Set1 complex (Wysocka et al., 2003; Goo et al., 2003; Hughes et al., 2004; Yokoyama et al., 2004).”
Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression (2004, background): “A recently reported meninMLL2 (the closest homolog of MLL) complex also contains ASH2L and RBBP5 (27).”
The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis (2012, background): “This biochemical study demonstrated that not only is MLL2 associated within a COMPASSlike complex, but it can also function as a histone H3K4 methylase (56).”