SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

By D. Wald, J. Qin, Zhendong Zhao, Youcun Qian, M. Naramura, Liping Tian, J. Towne, J. Sims, G. Stark, Xiaoxia Li. Nature Immunology, 2003

643 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/8df31fd4cd859e9e9f7f4ff21d4902d21be53578

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. Luke A. O'Neill
5. K. Takeda
6. T. Mogensen
7. A. West
8. Aly Karsan

In Immunology

1. Shizuo Akira
2. S. Ghosh
3. T. Mogensen
4. Luke A. O'Neill
5. M. Hayden
6. C. Garlanda
7. K. Takeda
8. A. West

Citations in the corpus

• The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I1 (2005, background): “functions as an inducible decoy receptor, sequestering IL-1 (43), MyD88s, an inducible splice variant of MyD88 that inhibits IL-1 and TLR signaling by blocking IRAK-4 recruitment to these receptors (44), and single Ig IL-1R-related molecule, a differentially expressed inhibitory regulator for IL-1 a”
• TLR Signaling in the Gut in Health and Disease1 (2005, background): “(23) have shown that intestinal epithelial cells express high levels of a novel, TIR-containing inhibitory molecule called SIGIRR (single Ig IL-1R-related molecule) or Tir8.”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “In a large epidemiological study, heterozygosity of a Mal Ser180Leu functional variant has been associated with protection from invasive pneumococcal disease, bacteremia, malaria, and tuberculosis (185).”
• THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE (2013, positive): “…following stimulation of IL-1R family members or TLRs (IL-1RI, IL-18R, ST2, TLR1, TLR2, TLR3, TLR4, TLR7, and TLR9) (Bulek et al., 2009; Garlanda et al., 2004; Lech et al., 2008; Wald et al., 2003), by interfering with the recruitment of TIR-containing adaptor molecules (Wald et al., 2003).”
• Negative regulation of Toll-like receptor-mediated immune responses (2005, background): “Like ST2L, SIGIRR is an orphan receptor that does not induce NF-κB activatio”
• Toll-like receptors in innate immunity. (2004, positive): “In both SIGIRR-and T1/ST2-deficient mice, the LPS-induced inflammatory response was enhanced (116,117).”
• Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, background): “Single immunoglobulin IL-1R-related molecule ( SIGIRR ; also known as TIR8), which is a negative regulator of IL-1R, IL-33R, TLR4 and TLR9 signallin”
• Lipopolysaccharide signaling in endothelial cells (2006, background): “SIGIRR is thought to play a role in regulation of inflammatory events as its expression is downregulated in tissues of mice injected with LPS”
• NF-κB and the immune response (2006, background): “SIGIRR (TIR8), a member of the IL-1R family, binds to Toll/IL-1 receptors, IRAK and TRAF6 and may also function by inhibiting the association of IRAK with TLRs (Thomassen et al., 1999; Wald et al., 2003).”
• Toll-like receptor signalling (2004, background): “SIGIRR-deficient mice were found to be highly sensitive to LPS-induced endotoxic shoc”
• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (2005, background): “Instead, both receptors have been identified as negative regulators of TLR-IL-1 receptor signaling (Brint et al., 2004; Wald et al., 2003).”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “A similar example is provided by the single immunoglobulin IL-1 receptorrelated molecule (SIGIRR), which contains an intracellular Toll/IL-1 receptor (TIR) domain (88).”