Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

By T. Mogensen. Clinical Microbiology Reviews, 2009

2,945 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c0b48a406730b1ceedc48bbb7c8a6c0e3b33f1f2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Hoseinifar
2. C. Andersen
3. S. Davies
4. Jian Lei
5. M. Fernández
6. S. Kanoh
7. B. Rubin
8. Ting Liu

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. J. R. Kelly
6. C. Andersen
7. S. Davies
8. Min Wu

Citations in the corpus

• An Overview of Plant Immunity (2015, background): “It is thought that such infected cells produce some sort of signals which induces the adjacent cells to produce the phytoalexins, which are packaged in lipid vesicles and exported to the infected cell [43].”
• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein (2017, background): “For more information on the host innate immune system signaling pathways, the reader should consult other reviews (e.g., Mogensen, 2009; Lei and Hilgenfeld, 2017).”
• Gamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection (2014, background): “Activation of PRRs triggers intracellular signaling pathways culminating in the expression of inflammatory mediators which stimulate the maturation of antigen-presenting cells and initiation of adaptive immune responses, such as the development and proliferation of antigen-specific effector T-cell s”
• Boosting Immune Function and Disease Bio-Control Through Environment-Friendly and Sustainable Approaches in Finfish Aquaculture: Herbal Therapy Scenarios (2020, background): “They act as critical components in both innate and acquired types of immunity through intermolecular “cross-talks”, which maintain physiological stability (Mogensen 2009).”
• Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “The coordinated efforts of innate and adaptive immune systems allow for the targeted elimination of pathogens via proinflammatory mechanisms (24, 31).”
• Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “LPS, as the prototypical PAMP, can be recognized by multiple host receptors, including TLRs, PRRs, and nucleotide-binding oligomerization domain-like (NOD-like) receptors.(32) The LPS-PRRs/NOD-like molecules activate inflammasome to produce proinflammatory cytokines,(33,34) activating TNF-α and IL-1”
• NF-κB in biology and targeted therapy: new insights and translational implications (2024, background): “215,216 Additionally, PRRs are also involved in recognizing molecules called damage-associated molecular patterns (DAMPs), which are released by necrotic cells and damaged tissues.”
• Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications (2010, background): “The latter leads to the induction of AP-1, while the former activates NF- B through the degradation of I B proteins and the subsequent translocation of NF- B (194).”
• NF-κB signaling in inflammation (2017, positive): “19, 24 This latter function of TRIF signaling involves activation of an E3 ubiquitin ligase, Peli1, which conjugates lysine 63-linked ubiquitin chains to RIP1, thereby facilitating the recruitment and activation of IKK.”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “…axis disorder associated with an altered gut microbiota profile (Carroll et al., 2011; Jeffery et al., 2012c; Collins, 2014; De Palma et al., 2014a; Simrén, 2014; Soares, 2014; Rajilic-Stojanovic et al., 2015) and increased intestinal permeability (Dunlop et al., 2006; Rao et al., 2011;…”
• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “The innate immune system is activated by a limited number of receptors that can recognize pathogen-associated or damage-associated molecular patterns [159,160].”
• Gut Bacteroides species in health and disease (2021, background): “However, it is now established that zwitterionic-polysaccharides (carrying both negative and positive charges) such as PSA can induce CD4 T cell–dependent immune responses.(161) Toll like receptors (TLRs) comprise a family of transmembrane pattern recognition receptors that detect different but over”