Toll-like receptors in innate immunity.

By K. Takeda, Shizuo Akira. International Immunology, 2004

3,607 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/a6c2052e89e93f14b456696508fea049e8281b1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. M. Hayden
3. Shizuo Akira
4. H. Yanai
5. H. Hemmi
6. A. Takaoka
7. R. Steinman
8. Danyang Li

In Immunology

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. G. Núñez
5. H. Hemmi
6. H. Kono
7. Danyang Li
8. Minghua Wu

Citations in the corpus

• TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. (2005, methodology): “Since ERK and p38 MAP kinases are essential downstream molecules in TNFR1 and IL-1R/TLR-mediated signaling pathways (Baud and Karin 2001; Takeda and Akira 2005), we analyzed the kinetics of ERK and p38 MAP kinase activation by immunoblotting with antibodies specific for phospho-ERK1/2 and phospho-p3”
• Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “fungal, and protozoal pathogen-associated molecular patterns (PAMPs), and therefore are very important in innate immunity [ 107 ] .”
• Interferon signalling network in innate defence (2006, background): “…of IFNα / β genes are mediated by the activation of pattern recognition receptors (PRRs) including TLRs (Takeda et al ., 2003; Akira and Takeda, 2004; Takeda and Akira, 2005; Kawai and Akira, 2006) and retinoic acidinducible gene-I (RIG-I) and melanoma differentiationassociated gene 5 (Mda5)…”
• Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. (2006, background): “All TLRs except for TLR3 use the Myd88 for the production of inflammatory cytokines (Takeda and Akira, 2005).”
• Pattern recognition receptors in health and diseases (2021, background): “PRRS AND LIGAND-RECOGNITION MECHANISMS Toll-like receptors TLRs are membrane-bound signal receptors and are important PRRs in the innate immune system of vertebrates.(15,33) Such receptor molecules usually have two functions, one is to bind specifically to the ligand, and the other is to transmit si”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “identified [166, 167], and these are discussed in detail in other chapters of this book.”
• The Role of Synovitis in Osteoarthritis pathogenesis (2012, background): “Stimulating ligands have been identified for TLR1– 9 [103], and include microbial and endogenous host products.”
• Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. (2007, background): “These receptors represent a conserved family of innate immune recognition receptors that play key roles in detecting microbes, initiating innate immune responses, and linking innate and adaptive immunity (Takeda and Akira, 2005).”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “These PAMPs often play a critical function in the life of the microbe and include lipopolysaccharide (LPS), a major component of the outer layer of Gram-negative bacteria, peptidoglycan (PGN), the main component of the cell wall of Gram-positive bacteria, flagellin, and microbial nucleic acids.”