THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE
By C. Garlanda, C. A. Dinarello, A. Mantovani. Immunity, 2013
1,868 citations recorded by the source corpus.
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes 7 ligands with agonist activity (IL-1α and β, IL-18, IL-33, IL-36α, β, γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38) and an anti-inflammatory cytokine (IL-37). Members of the IL-1 Receptor (IL-1R) family include 6 receptor chains forming 4 signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP) and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb). A tight regulation via receptor antagonists, decoy receptors and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. All cells of the innate immune system express and/or are affected by IL-1 family members. Moreover, IL-1 family members play a key role in the differentiation and function of polarized innate and adaptive lymphoid cells. Here we will review the key properties of IL-1 family members, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/d23aa6421884cdd6a346a7fd8cd5d7d7c63b438c
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Citations in the corpus
- IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. (2014, background): “IL-33 is a nuclear cytokine, initially designated NF-HEV [1,2], which exhibits structural similarities with IL-1 [3 – 6].”
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- Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy (2017, background): “Interleukin-1 (IL-1) was the first cytokine to be discovered, and although 11 different molecules compose the family (IL-1α, IL1-β, IL-18, IL-33, IL-36α, IL-36β, IL36γ, IL-1Ra, IL-36Ra, IL-38, IL-37), often only IL-1α and -1β are considered when referring to IL-1 [63].”
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