The Microbiome in Infectious Disease and Inflammation

By K. Honda, Dan R. Littman. Annual Review of Immunology, 2012

753 citations recorded by the source corpus.

The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/103a3a65b657973b074c47b82e3ede11dd0d273f

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Citations in the corpus

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “For example, some bacteria play beneficial roles for the host by supplying essential nutrients and aiding in the digestion of otherwise indigestible compounds (3).”
The Host Shapes the Gut Microbiota via Fecal microRNA (2016, positive): “Given the importance of gut microbiota in host physiology and pathology (Honda and Littman, 2012), our findings reveal a host defense mechanism and highlight miRNA as a strategy for specific manipulation of microbiome for the health of the host.”
Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity (2012, background): “The largest andmost diversemicrobial communities reside in the intestine and have beneficial properties ranging from aiding in metabolism to competing with invasive pathogens for the environmental niche (Honda and Littman, 2012; Sonnenburg et al., 2006).”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “In the immunology field, the possibility that the microbiome can regulate systemic immunity is gaining more support [145].”
Activation of the receptor (Gpr109a) for niacin and the commensal metabolite butyrate suppresses colonic inflammation and carcinogenesis (2014, neutral): “Commensal microbiota in the gut have profound effects on human health (Bäckhed et al., 2005; Honda and Littman, 2012).”
Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. (2012, background): “Emerging data support the role of the intestinal microbiota in thematuration of immunity including the differentiation of regulatory Treg populations (Honda and Littman, 2012).”
Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “CD4Foxp3 Tregs are the most prominent regulatory cells in the body and are most abundant in the colonic lamina propria [90,91].”