NF-κB and the immune response

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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. (2010, background): “…T helper 1 (Th1) cell-polarizing cytokine IL-12 is restricted to macrophages and dendritic cells, even though this gene depends on an NF-kB protein (cRel) (Sanjabi et al., 2000) that is expressed in other immune (B and T lymphocytes) and nonimmune cells (e.g., fibroblasts) (Hayden et al., 2006).”
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. (2011, background): “The NF-kB pathway is critically involved in many aspects of the immune system, from the development of immune cells and organs to the proper functioning of innate and adaptive immunity (Hayden et al. 2006; Hoffmann and Baltimore 2006).”