Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

By M. Abreu. Nature reviews. Immunology, 2010

1,292 citations recorded by the source corpus.

Subfields: Food Science, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/79442878a84e4a545313d283779928010c83d785

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. Rana Al-Sadi
2. Danyang Li
3. Chang H. Kim
4. Minghua Wu
5. H. Said
6. Shuhong Guo
7. Jeongho Park
8. Ted G. Dinan

In Immunology

1. Rana Al-Sadi
2. Danyang Li
3. Minghua Wu
4. H. Said
5. Shuhong Guo
6. Ted G. Dinan
7. A. Fasano
8. G. Clarke

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. J. R. Kelly
6. Rana Al-Sadi
7. Danyang Li
8. Chang H. Kim

Citations in the corpus

• Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 (2014, positive): “However, thus far few discrete mechanisms have emerged (Abreu, 2010; Chen et al., 2010; Kelly et al., 2004; Patel et al., 2012).”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “As well as playing a role in maintaining intestinal barrier function (Cario et al., 2004; Rakoff-Nahoum et al., 2004), TLRs also promote epithelial cell proliferation, secretion of IgA into the gut lumen and expression of antimicrobial peptides (Abreu, 2010).”
• Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (2011, neutral): “These lectins are secreted into the intestinal lumen and enhance the clearance of Gram-positive bacteria (Abreu, 2010).”
• Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. (2013, background): “To assess the in vivo effects of LPS, we also developed an in vivo mouse model of LPS modulation of intestinal barrier function, which closely recapitulates the plasma LPS levels reported in the clinical studies.11e13,24e27 To establish the appropriate LPS dose to 385 use in the in vivo studies, mic”
• Gut Microbial Metabolites Fuel Host Antibody Responses. (2016, background): “Numerous microbial products, including proteins, polysaccharides, and molecules that activate pattern recognition receptors (PRR), such as Toll-like receptors (TLR) and NODlike receptors (NLR), stimulate the mucosal immune system (Abreu, 2010).”
• Pattern recognition receptors in health and diseases (2021, background): “TLR2 can recognize peptidoglycans and lipopeptides that infect intestinal epithelial bacteria and produce anti-infection and other immune-protective effects.(323) Studies have shown that the expression level of TLR2 protein in colon cancer is significantly upregulated compared with normal epithelial”
• Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. (2011, background): “Zonulin can activate EGFR through direct binding (1) and/or through PAR2 transactivation (2).”
• How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, neutral): “[99]).”