Toll-like receptor signalling

By Shizuo Akira, K. Takeda. Nature reviews. Immunology, 2004

8,647 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/51ded134fd70bec770564191ceccfba1dc4c7d1a

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Citations in the corpus

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. (2006, background): “During a gram-negative bacterial infection, LPS initiates the innate immune response through the TLR4 signaling pathway (23).”
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus (2005, methodology): “b–d, 293T cells were analysed for IFN-bdependent luciferase activity after co-transfection with (1) an IFN-b reporter plasmid, (2) the indicated siRNAs, and (3) RIG-I, Trif or an empty vector (b), or after co-transfection as above and infection with Sendai virus (SenV) (c), or after co-transfection ”
Lipopolysaccharide signaling in endothelial cells (2006, background): “58 These adaptors include myeloid differentiation factor 88 (MyD88), MyD88 adaptor-like protein (Mal), also called TIRAP, TIR-containing adaptor inducing IFN β (TRIF), also known as TIRAP-1 (TICAM-1), and TRIF-related adaptor molecule (TRAM), also called TIRAP-2 (TICAM-2)”
Toll-like receptor function and signaling. (2006, background): “Nucleic acids are also important MAMPs recognized by TLRs.8,9 Bacterial and viral DNA contains a high frequency of unmethylated CpG motif, and this sequence confers immune adjuvant activity through TLR9.”
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “Depending on the particular receptor engaged, this process leads to the activation of a transcriptional response program that includes nuclear factor 𝜅B (NF-𝜅B), followed by the production and secretion of cytokines, chemokines, and nitric oxide (NO) [32–34].”
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009, background): “We therefore tested whether fibrillar β-amyloid peptide (1-42) (Aβ1-42) could activate TLR4-TLR6 signaling via CD36.”
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells (2010, background): “TLR ligation results in the rapid activation of signal-dependent transcription factors, including members of the nuclear factor-κB (NF-κB), activator protein 1 (AP1) and interferon regulatory factor (IRF) familie”
Essential function for the kinase TAK1 in innate and adaptive immune responses (2005, background): “The initial recognition of invading pathogens is mediated by Toll-like receptors (TLRs), which detect distinct pathogen-associated molecular pattern”
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, background): “Immunostimulatory CpG MOTIFS , which are present in bacterial DNA but rarely found in vertebrates, are recognized by the pattern-recognition receptor Toll-like receptor 9 (TLR9”
Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. (2014, background): “The innate immune system possesses receptors that have evolved to recognize the patterns of such molecules [13,14].”
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 (2005, neutral): “Several proteins that recognize viral RNA have been discovered, including Toll-like receptors TLR3, 7, and 8 (Akira and Takeda, 2004).”