Toll-like receptors and innate immunity

By Satoshi Uematsu, Shizuo Akira. Journal of molecular medicine, 2006

3,110 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8a3f06ce520b8466032eee1adc0c555c80570762

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Citations in the corpus

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005, unknown): “dtd" [ ]> In mammalian innate immunity, pathogen-associated molecular patterns are recognized by specific Toll-like receptors (TLRs), culminating in activation of signaling pathways of the transcription factor NF-κB and the mitogen-activated protein (MAP) kinases Jnk a”
Toll-like receptor control of the adaptive immune responses (2004, background): “The main pathway by which DCs become activated and mature to provide the second signal to naive T cells occurs via the TLR recognition of PAMP”
Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. (2004, background): “The most studied PRRs are probably the family of at least 10 toll-like receptors (TLRs) (named after the toll receptor, first identified in the fruit fly, drosphophila) that are present at the cell surface as transmembrane receptors (17).”
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord (2009, background): “, hallmarks of M1 macrophage activation (Medzhitov, 2001).”
Pathogen Recognition by the Innate Immune System (2011, background): “The genomic DNA and hematin crystals of Trypanosoma and Plasmodium species, respectively, are sensed by TLR9 [2, 3, 6, 20].”
A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, unknown): “Infectious organisms trigger inflammation through activation of receptors that recognize pathogen-associated molecular patterns (PAMPs), such as cell wall components and nucleic acids (23).”
Immunomodulatory functions of type I interferons (2012, background): “TLRs are the key sensors of microbial invasion in mammal”
The Role of TLR2 in Infection and Immunity (2012, background): “TLR2 LIGANDS FOR PATHOGEN RECOGNITION Toll-like receptor receptors are type I integral transmembrane glycoproteins composed of a conserved intracellular toll–interleukin1 receptor (TIR) homology domain, a single transmembrane helix domain and a solenoid ectodomain (Kumar et al., 2009).”
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors (2005, background): “jpg" NDATA ITEM> ]> The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunit”
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8 (2005, unknown): “All TLRs are type I integral membrane proteins with extracellular leucine-rich regions and intracellular regions that are homologous to the IL-1R signaling Toll IL-1R domain (1, 2).”
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia (2013, background): “TLRs are expressed on innate immune system cells, including microglial and astroglial cells (Akira 2001; AlfonsoLoeches et al., 2010; Bowman et al., 2003; El-Hage et al., 2011; Kielian 2006).”
Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 (2004, background): “The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is an immune system modulator and induces expression of the TLR coreceptor CD14.”
Negative regulation of Toll-like receptor-mediated immune responses (2005, background): “It is essential for provoking the innate response and enhancing adaptive immunity against pathogen”