A cytokine-mediated link between innate immunity, inflammation, and cancer.

By Wan-Wan Lin, M. Karin. Journal of Clinical Investigation, 2007

1,972 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/97489a75966e0e8b9dcaffe48340b6a44d0e7ece

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. M. Karin
5. Guido Kroemer
6. C. Garlanda
7. S. Grivennikov
8. L. Zitvogel

In Molecular Biology

1. Zena Werb
2. E. Nakasone
3. M. Egeblad
4. Bharat B. Aggarwal
5. Subash C. Gupta
6. J. Kundu
7. A. Sica
8. B. Spiegelman

In Oncology

1. A. Mantovani
2. M. Karin
3. A. Sica
4. P. Allavena
5. Zena Werb
6. Bharat B. Aggarwal
7. S. Grivennikov
8. C. Garlanda

Citations in the corpus

• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, background): “A reporter for Upd transcription (UpdlacZ) (Chao et al., 2004) was also induced after JNK activation or EC ablation (Figures 3B–3D), mainly in small progenitor cells and larger MyoIA cells (GFP ), which we believe are early, partially differentiated ECs.”
• The role of exercise and PGC1α in inflammation and chronic disease (2008, background): “In addition, a systemic increase in the concentration of inflammatory cytokines stimulates the initiation of tumours, as well as their promotion and progressio”
• Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression (2010, background): “Furthermore, we found that the tumor-promoting effect of obesity in HCC depends to a large extent on the low-grade inflammatory response it induces, which involves elevated production of TNF and IL-6, both of which are tumor-promoting cytokines (Lin and Karin, 2007).”
• The Gut Microbiome Modulates Colon Tumorigenesis (2013, background): “Chronic inflammation of the colon leads to the production of various inflammatory cytokines and reactive oxygen species that work in concert to generate a tumor microenvironment that promotes carcinogenesis (21, 23, 24).”
• NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review (2015, background): “The NF-κB family is suggested to be the most extensively studied target in inflammation issue for its critical role (Chen and Greene, 2004; Lin and Karin, 2007).”
• Cytokine signaling modules in inflammatory responses. (2008, background): “Rather, inflammation is increasingly linked to chronic diseases such as coronary artery disease, obesity, and cancer (Lin and Karin, 2007).”
• Immunological aspects of cancer chemotherapy (2008, background): “Instead, pro-inflammatory cytokines (such as IL-1β, TNF and IL-6) that are produced by either the tumour or host immune cells may promote tumour progression through a molecular signalling pathway that involves nuclear factor-κB (NF-κB”
• The Roles of Autophagy in Cancer (2018, background): “These cytokines play crucial roles in inducing chronic inflammation and have anticancer effects as well as contribute to cancer progression via inflammation [98].”
• The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “Importantly, also tumour initiation, promotion and progression are stimulated by systemic elevation of pro-inflammatory cytokines (Lin & Karin, 2007; Handschin & Spiegelman, 2008).”
• The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. (2011, background): “Consistently, constitutive production of TNF from the tumor microenvironment is seen in many malignant tumors and is frequently associated with poor prognosis (Lin and Karin, 2007).”
• Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, background): “Moreover, IL-10 can exert antitumoral activity in gliomas, melanomas, and breast and ovarian carcinomas [98], through a mechanism involving MHC-I downregulation, thus inducing NK-mediated tumor cell lysis [99].”
• Immunity, Inflammation, and Cancer (2010, neutral): “It is the expression of various immune mediators and modulators as well as the abundance and activation state of different cell types in the tumor microenvironment that dictate in which direction the balance is tipped and whether inflammation-promotes tumor growth or anti-tumor immunity will ensue (”
• Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “These cytokines control and mediate the cross-talk between cancer cells and tumor infiltrating immune and inflammatory cells and are responsible for inflammation-promoted tumor growth and inhibition of tumor immunosurveillance (86).”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “in and may predispose the host to various chronic illnesses, including cancer [68].”