ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

By A. Matsuzawa, K. Saegusa, T. Noguchi, C. Sadamitsu, H. Nishitoh, S. Nagai, S. Koyasu, K. Matsumoto, K. Takeda, H. Ichijo. Nature Immunology, 2005

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Toll-like receptor activation of XBP1 regulates innate immune responses in macrophages (2010, background): “TRAF proteins can bind and activate NADPH oxidase, a membrane-bound enzyme complex found in the plasma membrane as well as in phagosome membrane”
Are innate immune signaling pathways in plants and animals conserved? (2005, background): “Work in mammalian cells and with 'knockout' mice has also suggested that the p38 MAPK pathway is a more ancient component of innate immune signaling than is NF-κ”
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “In mice, genetic analysis has recently demonstrated a similar role for ASK1, the mammalian NSY-1 homolog, in immunity [6].”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Moreover, Matsuzawa et al. (2005) showed that ASK1, a member of the MAPK kinase–kinase (MAP3K) family, specifically mediates a branch of TLR4 signaling through a reactive oxygen species (ROS)-dependent pathway.”
Cytokines in Radiobiological Responses: A Review (2012, positive): “This ASK1 pathway is required for pro-inflammatory cytokine production through TLR4 and p38 signaling pathways (105).”