Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1

By Tian-tian Wang, F. P. Nestel, V. Bourdeau, Yoshihiko Nagai, Qiuyu Wang, J. Liao, Luz E. Tavera-Mendoza, R. Lin, J. Hanrahan, S. Mader and 1 more. Journal of Immunology, 2004

1,158 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/c3217b389309274fac0d7a1b9a629552f8b81706

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In Immunology

1. D. Bikle
2. F. Di Virgilio

Citations in the corpus

• Vitamin D: modulator of the immune system. (2010, background): “Besides CAMP, also the gene encoding the antimicrobial peptide, defensin b2, was identified as direct a target for 1,25(OH)2D3 [29].”
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1 (2006, positive): “1 ,25(OH)2D3 is known to induce the expression of the hCAP-18 gene that encodes the antimicrobial peptide LL-37 (39).”
• Nonclassic actions of vitamin D. (2009, background): “Lack of substrate (25OHD), VDR, or CYP27B1 blunts the ability of these cells to respond to a challenge with respect to cathelicidin production (14, 16, 69).”