Pathogen Recognition by the Innate Immune System

By Himanshu Kumar, Taro Kawai, Shizuo Akira. International Reviews of Immunology, 2011

2,192 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/75985da9cdcc6adf12edfcc2693ecec68c869c8d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Otto
2. Antero Salminen
3. J. Schorey
4. K. Kaarniranta
5. T. Kanneganti

In Molecular Biology

1. Prachi Singh
2. Yong Cheng
3. V. L. Smith
4. M. Otto
5. J. Upton
6. William J. Kaiser
7. J. Schorey
8. E. Mocarski

Citations in the corpus

• Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. (2014, background): “The innate immune system possesses receptors that have evolved to recognize the patterns of such molecules [13,14].”
• Exosomes and other extracellular vesicles in host–pathogen interactions (2014, positive): “The importance of PRRs in the recognition and response to pathogens has been shown in both animal infection models and human studies [1].”
• Inflammation and its role in age-related macular degeneration (2016, background): “The ligand recognition process triggers the activation of intracellular signaling pathways resulting in the production of numerous pro-inflammatory mediators [34].”
• NF-κB signaling in inflammation (2017, neutral): “18,20,21 The different families of PRRs have distinct structural properties and respond to different PAMPs and DAMPs, but they share many similarities in the downstream signal transduction pathways.”
• Pathogenicity and virulence of Staphylococcus aureus (2021, background): “and usually activate Toll-like receptors (TLRs) [57], which function as homo- or heterodimers.”
• The crucial roles of inflammatory mediators in inflammation: A review (2018, background): “The mechanism of phagocytosis needs the employment of actin filaments during internalization response [98].”
• DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. (2015, background): “Type I interferons (IFNs), the main effector cytokines against viral infections, are inducedmainly via the activation of pattern-recognition receptors (PRRs) such as Toll-like receptors (TLRs), RIG-Ilike receptors (RLRs), and the newly identified STING-dependent pathways that recognize microbial and”
• Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL* (2013, background): “TLRs, like TNF family death receptors, mediate cytokine and interferon activation (3), while also hold-”