The Role of TLR2 in Infection and Immunity
By L. Oliveira-Nascimento, P. Massari, L. Wetzler. Front. Immun., 2012
770 citations recorded by the source corpus.
Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. This review will discuss the current status of TLR2 mediated immune responses by recognition of pathogen-associated molecular patterns (PAMPS) on these organisms. We will emphasize both canonical and non-canonical responses to TLR2 ligands with emphasis on whether the inflammation induced by these responses contributes to the disease state or to protection from diseases.
View Paper: https://www.semanticscholar.org/paper/255e2ae685132deb67ca0438f2d722c42a809743
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Sandra N. Lester
- Kui Li
- Guangping Gao
- Wei Zhan
- Thomas L. Gallagher
- Jiang-Hui Wang
- Dominic J. Gessler
Citations in the corpus
- Adeno-associated virus as a delivery vector for gene therapy of human diseases (2024, background): “426 It can further expand its ligand recognition repertoire by forming heterodimers with TLR-1 and TLR-6. rAAV2 and rAAV8 both activate NF-κ B-mediated cytokine expression in human liver cells in a TLR-2-dependent manner.”
- Toll-like receptors in antiviral innate immunity (2013, background): “The outcome is the induction of proinflammatory cytokines and chemokines [161].”