Immunomodulatory functions of type I interferons
By J. González-Navajas, Jongdae Lee, M. David, E. Raz. Nature reviews. Immunology, 2012
1,033 citations recorded by the source corpus.
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these cytokines in host defence and homeostasis than was originally assumed. The main focus of this Review is the underappreciated immunomodulatory functions of type I IFNs in health and disease. We discuss their function in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflammasome activation, intestinal homeostasis and inflammatory and autoimmune diseases.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/c59b2c666d7c3026636684e55ef490246b583712
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In Immunology
Citations in the corpus
- Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “IFN-I provides no any therapeutic benefit in IBD, it may even exacerbate the disease [33].”
- TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria (2012, neutral): “ISGF3 translocates to the nucleus and initiates transcription of multiple IFN-stimulated genes (ISGs) (González-Navajas et al., 2012).”
- Bifidobacteria-mediated immune system imprinting early in life (2020, background): “Additionally, there is preclinical evidence of Treg cell mediated protection in a rodent colitis models whereby both intestinal inflammation and cytokine secretion is decreased by exogenous IFNβ (González-Navajas et al., 2012).”
- The Hippo signalling pathway and its implications in human health and diseases (2022, neutral): “343,344 YAP negatively regulates IFN-β signalling.”