Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

By A. Takaoka, H. Yanai, S. Kondo, G. Duncan, Hideo Negishi, T. Mizutani, Shin-ichi Kano, K. Honda, Y. Ohba, T. Mak and 1 more. Nature, 2005

1,090 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/4248fe4d8ebcfe35f3cae109f6e16fa1fd9df810

How researchers see this paper

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In Cancer Research

1. Shizuo Akira
2. Taro Kawai
3. Luke A. O'Neill
4. T. Mogensen
5. T. Kaisho
6. R. Randall
7. S. Goodbourn
8. H. Hemmi

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. Zhijian J. Chen
4. R. Medzhitov
5. T. Mogensen
6. Jacques Banchereau
7. Luke A. O'Neill
8. Yong‐jun Liu

Citations in the corpus

• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “IRF5 is incorporated into the MyD88 complex and controls the induction of IL-6 and IL-12p40 (ref”
• IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “Consequently, Irf5 -deficient mice are resistant to lethal endotoxic shoc”
• Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TN”
• Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “IRF5 acts downstream of the TLR-MyD88 signaling pathway in the induction of proinflammatory cytokines (Takaoka et al., 2005).”
• Innate immune recognition of viral infection (2006, background): “In contrast to the critical function of IRF7 in type I interferon induction, IRF5 is required for proinflammatory cytokine induction rather than type I interferon induction by TLR3, TLR4, TLR7 and TLR9 (ref”
• The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (2007, background): “IRF5 was identified as being crucial for the induction of pro-inflammatory cytokines and type I IFNs by all TLRs teste”
• Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “IRF5 has previously been shown to be required for optimal expression of IL-12 and pro-inflammatory cytokines in mic”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “These molecules likely play critical roles in the link between innate and adaptive T cell immunity [172, 173].”