Toll-like receptor control of the adaptive immune responses

By A. Iwasaki, R. Medzhitov. Nature Immunology, 2004

4,488 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/022fc5c36993226553199dfd3a1d7ba6d5ce0eb7

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Citations in the corpus

Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “The main sentinel cells of innate immunity (epithelial cells, phagocytic cells and dendritic-cell (DC) subsets) simultaneously express overlapping but not identical combinations of TLRs and other PRR”
Epidemiology of and Diagnostic Strategies for Toxoplasmosis (2012, background): “Other phagocytic cells, such as dendritic cells (DCs) and macrophages, play a pivotal role in the initiation of innate immunity, as they are the major sources of IL-12 as well as IL-18, thus promoting natural killer (NK) and NKT cell activation (177), with both cell types producing IFN- in large qua”
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor (2008, neutral): “Proteins from lysates or purified phagosomes from RAW-TLR9 cells were immunoprecipitated with anti-HA resin and treated with EndoH (E), PNGaseF (P), or left untreated (2).”
Inflammatory responses and inflammation-associated diseases in organs (2015, background): “Signaling through transcription factors results in secretion of cytokines [42, 43].”
The interferon response circuit: Induction and suppression by pathogenic viruses (2005, neutral): “Human pDCs mostly express the TLR9 subfamily members TLR7, TLR8 and TLR9 which recognize viral single-stranded (ss) RNA (TLR7,8) or double-stranded CpG-rich DNA (TLR9), respectively (Iwasaki and Medzhitov, 2004).”
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, background): “Members of the Toll-like receptor (TLR) family have been linked to the induction of IL-12 production by DCs and the initiation of T H 1 response”
The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “More specifically, the bacterial wall component lipopolysaccharide (LPS) activates through TLR-4 and the cluster of differentiation (CD) molecule CD14, peptidoglycan through TLR-2, dsRNA through TLR-3, and CpG through TLR-9 (Iwasaki and Medzhitov, 2004).”
A cell biological view of Toll-like receptor function: regulation through compartmentalization (2009, background): “Key to this central role in host defence is the expression of TLRs on antigen-presenting cells, especially macrophages and dendritic cells (DCs”
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, background): “The detection and classification of invading pathogens by TLR and other PRR are carried out largely by cell types such as dendritic cells (DC) and macrophages that continually sample both the external environment at skin and mucosal surfaces, and the internal environment through cells circulating in”
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006, background): “The opposing effects of TLR7 and TLR9 on immune activation and disease severity were unexpected, since these two receptors are expressed in similar cell types and share downstream signaling pathways (Akira, 2003; Iwasaki and Medzhitov, 2004; Uematsu et al., 2005).”