Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease

By A. Swidsinski, J. Weber, V. Loening-Baucke, L. Hale, H. Lochs. Journal of Clinical Microbiology, 2005

852 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/72ca1b0dfc0c2a54db404c4ee8ff58599abbc2a6

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Citations in the corpus

Microbiota organization is a distinct feature of proximal colorectal cancers (2014, background): “Biofilms that invade the colonic mucus layer and come into direct contact with mucosal epithelial cells indicate a pathologic state (6, 7).”
Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces (2013, background): “Such a mechanism might be relevant to the understanding of inflammatory bowel disease which is, among others, associated with deregulated inflammatory responses to intestinal bacteria (139).”
Interactions and competition within the microbial community of the human colon: links between diet and health. (2007, background): “Microscopy has provided some evidence for the formation of surface-associated communities on mucosal surfaces in the colon, particularly in disease states such as inflammatory bowel disease (IBD) (Macfarlane et al., 2004; Swidsinski et al., 2005).”
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions (2010, methodology): “Patients with IBS served as controls without inflammation in a study that assessed the organization and composition of mucosa-associated microbiota in IBD”
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface (2008, result): “This idea is consistent with the observation of increased numbers of mucosa-adherent bacteria in IBD patients (31).”
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum (2007, background): “…et al., 2005) increased colonization by Enterobacteriaceae (Mylonaki et al., 2005) or the Gamma subdivision of Proteobacteria, Enterobacteriaceae and Bacteroides/ Prevotella (Kleessen et al., 2002), while others describe the presence of a non-invasive Bacteroides biofilm (Swidsinski et al., 2005).”
Towards the human intestinal microbiota phylogenetic core. (2009, background): “Its involvement in immune diseases has recently been demonstrated and bacterial imbalance or so-called ‘dysbiosis’ has been associated with pathologies such as inflammatory bowel disease and obesity (Marteau et al., 2004; Ley et al., 2005; 2006; Swidsinski et al., 2005).”
Mucin glycan foraging in the human gut microbiome (2015, result): “However, it is now clear that the composition of the mucosa-associated microbiota differs from that of the fecal microbiota in terms of relative abundance of the different phyla, although the results may vary between studies (Swidsinski et al., 2005; Frank et al., 2007; Carroll et al., 2010).”
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease (2011, background): “Similar shifts in composition, in either one or all of these groups, have been reported by other investigators using both culture [22] and a variety of molecular techniques [29,31,45-55].”
Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota (2007, background): “In line with findings in the murine system, antibiotics are known to reduce human colonization resistance, and altered microbiota composition is commonly observed in patients with inflammatory bowel disease (IBD) [32–34].”
Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model (2012, background): “Recent in vivo (Swidsinski et al., 2005; Sokol et al., 2008; Walker et al., 2011) and in vitro (Vermeiren et al., 2012) studies revealed that this disease correlates with lower levels of mucosal butyrate producers, including Roseburia and Faecalibacterium, indicating that a damaged mucus layer may…”
Immune adaptations that maintain homeostasis with the intestinal microbiota (2010, background): “For example, patients with IBD have increased numbers of epithelial cell surface-associated bacteri”
Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, neutral): “Gradually, lactobacilli have been investigated for their capacities to exert immunostimulatory (adjuvant) and immunoregulatory (e.g., in IBD) properties.”