Immune adaptations that maintain homeostasis with the intestinal microbiota

By L. Hooper, A. Macpherson. Nature reviews. Immunology, 2010

1,420 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/65cd81a51c8bfc8ae66cbf0604227395342153ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. J. Walter
2. G. Hajishengallis
3. F. Bäckhed
4. Patrice D Cani
5. H. Hamasalim
6. Ruth E. Ley
7. F. Powrie
8. P. Cossart

In Molecular Biology

1. F. Bäckhed
2. J. Walter
3. Y. Belkaid
4. Herbert Tilg
5. Patrice D Cani
6. Ruth E. Ley
7. O. Harrison
8. T. Hand

In Surgery

1. Y. Belkaid
2. S. Bischoff
3. M. Johansson
4. G. Hansson
5. F. Bäckhed
6. Patrice D Cani
7. R. Medzhitov
8. Herbert Tilg

Citations in the corpus

• Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “On a cellular level, the dynamic crosstalk between intestinal epithelial cells (IECs), intestinal microbes and local immune cells represents one of the fundamental features of intestinal homeostasi”
• The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “Of these, bacteria are the most abundant and can be found at concentrations as high as 10(9) cells/mL in the small intestine and 10(12) cells/ g of luminal content in the large intestine (1).”
• Human gut microbiome: hopes, threats and promises (2018, background): “21 Therefore, GI cells are continually exposed to a vast number of microbial antigens and metabolites.”
• Mechanisms and consequences of intestinal dysbiosis (2017, background): “This state of tolerance relies on multiple mechanisms such as a physical mucus barrier minimizing the contact to the epithelium, and the secretion of antimicrobial proteins and immunoglobulin A [120].”
• Gut Microbiota and its Modulation for Healthy Farming of Pacific White Shrimp Litopenaeus vannamei (2018, background): “The animal gut is a vital organ for food storage, digestion and nutrient absorption and plays an important role in immunity (Hooper and Macpherson, 2010; Ringø et al., 2016; Tzuc et al., 2014).”
• A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway (2011, background): “…mice under a controlled inflammatory state: a state which also characterizes clinically healthy human periodontal tissue (Darveau, 2010) and is analogous to the evier Inc. immunoinflammatory surveillance state described for the healthy intestine (Hooper and Macpherson, 2010; Slack et al., 2009).”
• Microbial Dysbiosis in Colorectal Cancer (CRC) Patients (2011, background): “Thus, DNA sequencing that targets hypervariable regions within small ribosomal-subunit RNA genes, especially 16S rRNA genes has made it possible to characterize the biodiversity of the microbiota, which could lead to diseases (for a review, see ref [8]).”
• The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions (2010, background): “How this occurs is not fully understood, but two major principles are involved: (i) minimizing bacterial–epithelial cell contact, and (ii) the immune system having a tolerant way of handling bacteria (9).”
• Intestinal permeability – a new target for disease prevention and therapy (2014, background): “The gut barrier plays a key role in the avoidance of inflammatory responses to the microbiota and is regulated by a finely tuned network of immune mechanisms for microbial recognition and tolerance to the microbiota [60,61].”
• How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “Finally, the 118 microbiota is involved in the regulation of the host immune system [23].”