Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

By Bärbel Stecher, Riccardo Robbiani, A. Walker, A. Westendorf, Manja Barthel, M. Kremer, Samuel Chaffron, A. Macpherson, J. Buer, Julian Parkhill and 3 more. PLoS Biology, 2007

1,057 citations recorded by the source corpus.

Most mucosal surfaces of the mammalian body are colonized by microbial communities (“microbiota”). A high density of commensal microbiota inhabits the intestine and shields from infection (“colonization resistance”). The virulence strategies allowing enteropathogenic bacteria to successfully compete with the microbiota and overcome colonization resistance are poorly understood. Here, we investigated manipulation of the intestinal microbiota by the enteropathogenic bacterium Salmonella enterica subspecies 1 serovar Typhimurium (S. Tm) in a mouse colitis model: we found that inflammatory host responses induced by S. Tm changed microbiota composition and suppressed its growth. In contrast to wild-type S. Tm, an avirulent invGsseD mutant failing to trigger colitis was outcompeted by the microbiota. This competitive defect was reverted if inflammation was provided concomitantly by mixed infection with wild-type S. Tm or in mice (IL10−/−, VILLIN-HACL4-CD8) with inflammatory bowel disease. Thus, inflammation is necessary and sufficient for overcoming colonization resistance. This reveals a new concept in infectious disease: in contrast to current thinking, inflammation is not always detrimental for the pathogen. Triggering the host's immune defence can shift the balance between the protective microbiota and the pathogen in favour of the pathogen.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/107ee61a281db717f543e3f565a81e41349b42aa

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Citations in the corpus

Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation (2013, background): “Typhimurium changes the composition of the microbiota and suppresses its growth, thereby offering Salmonella a growth advantage (147).”
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Microbes inside—from diversity to function: the case of Akkermansia (2012, background): “…organisms are universally distributed in the intestines of the animal kingdom ranging from humans and other mammals (Turnbaugh et al., 2006; Stecher et al., 2007; Ley et al., 2008; Tsukinowa et al., 2008; Sonoyama et al., 2009, 2010; Presley et al., 2010) to non-mammals such as zebrafish…”
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