Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

By Shipra Vaishnava, Cassie L. Behrendt, Anisa S. Ismail, L. Eckmann, L. Hooper. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,011 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/ba39f91e2c368762a51f9c6e0735282b8a86adfb

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Citations in the corpus

Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “…(Szentkuti et al., 1990), reduced gastric motility (Abrams & Bishop, 1967), improper development and functioning of intestinal cells and immune cells (Cahenzli et al., 2013; Vaishnava et al., 2008) and improper development of the immune system (Bauer et al., 1963; Macpherson & Uhr, 2004).”
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “…mice have shown that antibiotic treatment can reduce the capacity to fight infections by Gram-positive organisms by decreasing the expression of bactericidal compounds and diminishing neutrophil-mediated killing (Brandl et al., 2008; Vaishnava et al., 2008; Clarke et al., 2010; Ubeda et al., 2010).”
NLRP6 inflammasome is a regulator of colonic microbial ecology and risk for colitis (2011, neutral): “Epithelial cell lineages, notably the Paneth cell, sense bacterial products through receptors for microbe-associated molecular patterns (MAMPs), resulting in regulated production of bactericidal molecules (Vaishnava et al., 2008).”
Gut microbiota in health and disease. (2010, background): “The induction was mediated through TLR-MyD88 signaling (317).”
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment (2012, background): “Specific host pathways linked to microbial response in IBD include T-cell activation, the IL-23/T helper 17 pathway, autophagy [31], and Paneth cell function [32].”
The immune system and the gut microbiota: friends or foes? (2010, background): “Current results indicate that a trade-off is established between the host immune system and the bulk of the microbiota, so that in a healthy individual, intestinal colonization stimulates host production of microbicidal peptide”
The human gut microbiome: ecology and recent evolutionary changes. (2011, background): “, C-type lectins) are triggered by the presence of bacteria (103).”
How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “94 Indeed, whereas α-defensins are constitutively expressed, other antimicrobial peptides such as 95 REG3γ (Regenerating islet-derived protein 3γ) or cryptdins are produced in response to the 96 detection of pathogen-associated molecular patterns (PAMPs) that activates TLR (Toll-like 97 receptors) o”
The human gut microbiota: Metabolism and perspective in obesity (2018, background): “This event causes intestinal barrier dysfunction and increases bacterial translocation.(22) Furthermore, bacteria-induced myeloid differentiation factor 88 (MyD88) signaling in the intestine increases epithelial cell IgA secretion.”