Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
By Y. Wan, R. Flavell. Nature, 2007
916 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/6cb046cddaffbc82e22f1bd993da5e506dac505e
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In Immunology
- Alexander Y. Rudensky
- Shimon Sakaguchi
- W. E. Paul
- Jinfang Zhu
- T. Malek
- V. Kuchroo
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In Oncology
- Loise M. Francisco
- P. Sage
- Y. Kanno
- J. O’Shea
- Steven Z. Josefowicz
- W. E. Paul
- Arlene H. Sharpe
- Shimon Sakaguchi
Citations in the corpus
- Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “This suggests that it may also be possible to induce IL-4 expression in Treg cells; indeed, as discussed above, there are circumstances where this occurs (Wan and Flavell, 2007).”
- Foxp3 in control of the regulatory T cell lineage (2007, background): “This was convincingly demonstrated by the lymphoproliferative autoimmune disease in mutant mice dubbed 'FILIG', which show a substantially attenuated expression of intact Foxp3 protei”
- FOXP3+ regulatory T cells in the human immune system (2010, background): “Indeed, in mice, recent reports have highlighted the plasticity of T Reg cells towards effector T H 1, T H 2 or T H 17 cell phenotypes under pathological condition”
- Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, neutral): “Decreased Foxp3 expression in T regs has been reported in various autoimmune diseases including type 1 diabetes in NOD mice 1,3.”
- Differentiation of Effector CD4 T Cell Populations (2010, positive): “By contrast, limiting Foxp3 expression appears to divert cells that would have differentiated into Tregs to develop into Th2-like cells, implying a close relationship of the Th2 and Treg lineages (84).”
- IL-10: The Master Regulator of Immunity to Infection (2008, background): “They require IL-2 for both their maintenance in the periphery and for the production of IL-10 (58, 59); their suppressive function is linked to the expression of Forkhead box transcription factor 3 (Foxp3) (60).”
- Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “This relatively low-level FOXP3 expression in activated human T cells requires TGF-β produced by activated T cells or present in serum, and it does not result in acquisition of Treg cell phenotype and suppressor activity (27, 191).”
- The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “(130) demonstrated that Tregs from mice genetically engineered to express low levels of Foxp3 lose suppressive activity and simultaneously gain effector cell functions (IL-2, IL-4, IFN-c production).”
- Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…higher levels, thereby shifting the ROR/FOXP3 balance towards FOXP3 and Treg differentiation [Bettelli et al., 2006; Chen et al., 2003; Fantini et al., 2004; Korn et al., 2007a; Nurieva et al., 2007; Veldhoen et al., 2006; Wan and Flavell, 2007; Yang et al., 2008a; Zhou et al., 2008] (Figure 7).”
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “This finding is important because low expression of Foxp3 is not able to induce the Treg cell program (Wan and Flavell, 2007).”