Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

By Gang Wei, Lai Wei, Jinfang Zhu, Chongzhi Zang, J. Hu‐Li, Zhengju Yao, Kairong Cui, Y. Kanno, Tae-Young Roh, W. Watford and 6 more. Immunity, 2009

1,191 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e750dc963a781a87c621c7ad5ad44350384d8131

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Citations in the corpus

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection (2009, background): “Recent evidence also supports the idea that Treg cells can become unstable after exposure to defined stimulatory signals or in lymphopenic environments (Degauque et al., 2008; Duarte et al., 2009; Wei et al., 2009; Xu et al., 2007).”
Fast gene set enrichment analysis (2016, methodology): “As the example ranking Th0 vs Th1 comparison was used from dataset GSE14308 [4].”
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “In the case of histone modification, trimethylation of H3K4 is associated with active gene transcription, whereas trimethylation of H3K9, H3K27 and H4K20 is linked to silencing of gene expressio”
Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, result): “Together, these studies suggest that highly polarized inflammatory environments can subvert T Reg cell function by converting them to FOXP3 − effector T cells in vivo , and are consistent with a recent epigenetic analysis demonstrating that the loci encoding the key transcription factors and cyto”
Opposing regulation of the Il17 locus through direct, reciprocal actions of STAT3 and STAT5 (2011, background): “For efficient and stable gene transcription, the locus must be held in an open conformation, which can be monitored by the presence of characteristic histone modification”
Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, methodology): “and then processed for ChIP-Seq as previously described (Wei et al., 2009).”
Plasticity of CD4+ T cell lineage differentiation. (2009, background): “The experiments described above, using in vitro polarization or adoptive transfer, are representative of current approaches for studying Th17 cell stability (Lee et al., 2009; Croxford et al., 2009; Wei et al., 2009; Bending et al., 2009).”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “The NF-jB family member c-Rel is highly expressed in both nTregs and iTregs (94).”
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “Indeed, genome-wide histone-methylation analyses indicate that Tbx21 exists in a poised epigenetic state in T reg cells and can readily be upregulated in T H 1-polarizing conditions in vitro”
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (2012, methodology): “We therefore checked possible nTreg-specific histone modifications by using available chromatin databases of T cell subsets (Wei et al., 2009).”
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009, background): “…mapping has revealed numerous combinatorial patterns of histone modifications in human CD4+ T cells (Barski et al., 2007; Wang et al., 2008) and suggested that modification patterns can indicate differentiation potential of cells (Cui et al., 2009; Wei et al., 2009; reviewed in Wang et al., 2009).”
Development and maintenance of regulatory T cells. (2013, background): “In addition, enhanced H3K4me3 histone modification of the Treg cell signature genes detected in nTreg cells is easily primed in Tconv cells under a Th1-, Th2-, or Th17-cell-polarizing or iTreg-cell-inducing condition (Wei et al., 2009) (Figure 1).”