Arlene H. Sharpe

Immunology · 2000–2021

A researcher in the Science corpus: 32 papers; trusts 21 researchers and is trusted by 37 researchers here, as inferred from the citation graph.

Subfields

• Immunology — 540 citations into it; #57 of 2,160 by trust here, #26 by citations
• Oncology — 380 citations into it; #36 of 1,698 by trust here, #28 by citations

Whom Arlene H. Sharpe trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. Taku Okazaki
2. G. Freeman
3. Lieping Chen
4. E. Wherry
5. Daniel L. Barber
6. James L. Riley
7. R. Parry
8. D. Pardoll
9. Kristen E. Pauken
10. M. Butte

Who trusts Arlene H. Sharpe overall

1. E. Wherry
2. James L. Riley
3. Herbert W. Virgin
4. Daniel L. Barber
5. Loise M. Francisco
6. G. Dranoff
7. Lieping Chen
8. B. Fife
9. Rafi Ahmed
10. D. Pardoll

Papers from Arlene H. Sharpe's perspective

Ordered by how strongly the researchers Arlene H. Sharpe trusts endorse each paper. Same corpus, a different order for every researcher.

1. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. (Science)
2. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade (Proceedings of the National Academy of Sciences of the United States of America)
3. SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1 (Journal of Immunology)
4. Restoring function in exhausted CD8 T cells during chronic viral infection (Nature)
5. Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity (Nature Medicine)
6. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. (Immunity)
7. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection (Nature Immunology)
8. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. (Immunity)
9. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma (Nature Medicine)
10. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. (Cancer Research)

Their papers

• Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice (2000) — 1,247 citations
• p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours (2000) — 1,072 citations
• Spatially organized multicellular immune hubs in human colorectal cancer (2021) — 691 citations
• Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma (2020) — 821 citations
• Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity (2020) — 622 citations
• Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade (2019) — 1,754 citations
• LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade (2018) — 596 citations
• Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent (2017) — 903 citations
• The diverse functions of the PD1 inhibitory pathway (2017) — 1,681 citations
• Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy (2016) — 1,792 citations
• Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade (2016) — 871 citations
• Coinhibitory Pathways in Immunotherapy for Cancer. (2016) — 862 citations
• Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth (2015) — 616 citations
• Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses (2014) — 877 citations
• Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens (2014) — 1,894 citations
• The PD-1 Pathway in Tolerance and Autoimmunity (2010) — 2,180 citations
• PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells (2010) — 708 citations
• PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009) — 2,028 citations
• Costimulatory molecule ICOS plays a critical role in the development of TH-17 and follicular T-helper cells by regulating c-Maf expression and IL-21 production (2008) — 746 citations
• PD-1 and its ligands in tolerance and immunity. (2008) — 5,308 citations