Foxp3 in control of the regulatory T cell lineage

By Ye Zheng, Alexander Y. Rudensky. Nature Immunology, 2007

746 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/28721cd657d7e9482967dd64f0c991ebc7ddcac9

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Citations in the corpus

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? (2009, background): “Introduction The transcription factor Foxp3 is essential to establish a functional regulatory T (Treg) cell lineage (Fontenot et al., 2003; Hori et al., 2003; Khattri et al., 2003; Sakaguchi et al., 2008; Zheng and Rudensky, 2007).”
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells (2011, background): “Many aspects of the differentiation and function of T reg cells are controlled by the forkhead family transcription factor Foxp3 (ref”
IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “Both types of Treg cells express the Foxp3 transcription factor and IL-2Ra (CD25) [52], and IL-2 is required for their normal development [51].”
Fat Treg cells: a liaison between the immune and metabolic systems (2009, background): “T reg cells, a small subset of T lymphocytes, normally constituting only 5–20% of the CD4 + compartment, are thought to be one of the body's most crucial defenses against inappropriate immune responses, operating in contexts of autoimmunity, allergy, inflammation, infection and tumorigenesi”
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “The transcription factor Foxp3, essential for Treg development, maintenance, and functions, can be induced by TGFb-1 and IL-2, as well as retinoic acid, in peripheral naive CD4+ T cells ex vivo (Elias et al., 2008; Lohr et al., 2006; Miyara and Sakaguchi, 2007; Zheng and Rudensky, 2007).”
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10 (2007, background): “Expression of the transcription factor Foxp3 is a defining feature of natural T reg cell”
The Microbiome in Infectious Disease and Inflammation (2012, positive): “Foxp3 is critical to the initiation and maintenance of a genetic program for the differentiation and function of Treg cells (212).”
MicroRNA control in the immune system: basic principles. (2009, background): “Regulatory T cells require stronger signals from their TCR to be positively selected than do T cells of other subsets (Zheng and Rudensky, 2007), hinting at the possibility that miRNAs may be involved in the control of the”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “FOXP3 is predominantly expressed in CD4+CD25+ Treg cells, where it plays an important role in directing differentiation [Campbell and Ziegler, 2007; Lochner et al., 2008; Zheng and Rudensky, 2007].”