IL-10: The Master Regulator of Immunity to Infection

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Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II (2016, background): “, 1994) and suppress inflammation more generally (Couper et al., 2008).”
CD4+T Cells: Differentiation and Functions (2012, background): “IL10 is a potent inhibitory cytokine, with the ability to suppress proinflammatory response and thus limits tissue damage by the inflammatory process [131, 147, 148].”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “Consequently, a low-grade low-pathology but chronic infection is maintained (Bogdan 2008; Couper et al. 2008; Raes et al. 2007; Wynn et al. 2004).”
Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “However, high production of IL-10 is associated with sustained chronic infections and its blockade promotes pathogen clearance [27].”
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “The effects of IL-10 may be direct on T cells through STAT-3, indirect via modulation of APCs, or both (146).”