Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

By D. Webb, J. Parsons, A. Horwitz. Nature Cell Biology, 2002

818 citations recorded by the source corpus.

Subfields: Biomaterials, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/643fe0caba6369cbedf826eaa16050017f66a29e

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Citations in the corpus

Intravital imaging of cell movement in tumours (2003, background): “The rapid speed and shape of the tumour cells that are associated with ECM fibres that have been observed in vivo confirms this, as stable focal adhesions would slow movement considerably and cause the elongation of cells along ECM fibres because of the development of tension in cell”
Integrin signalling during tumour progression (2004, background): “Contraction of the stress fibres allows cells to pull forward, as older adhesion complexes at the trailing edge are disassemble”
To move or not to move? (2004, background): “Moreover, some migrating cells and axons express both receptors and ligands on the cell surface (Winberg et al, 1998), or secrete semaphorins in an autocrine fashion (for example, see Serini et al, 2003; Catalano et al, 2004).”
Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering (2010, background): “Through binding to these functional cell binding domains, integrins play central roles in the tissue development, organization and maintenance, by providing anchorage and triggering signals that direct cell function, cell-cycle progression, and expression of differentiated phenotypes [91,96,97].”
Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion (2005, background): “…these adhesions must be destabilized and released, coupled with depolymerization of the actin cytoskeleton to retract the cell’s trailing edge (DiMilla et al., 1993; Lauffenburger and Horwitz, 1996; Sheetz et al., 1998; Horwitz and Parsons, 1999; Webb et al., 2002; Webb and Horwitz, 2003).”
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. (2006, background): “Fast Migration Correlates with Intermediate Focal-Adhesion Lifetime and Rapid Renewal of Focal-Adhesion Components Two key steps in migration are FA formation and disassembly (Webb et al., 2002).”
Conserved microtubule–actin interactions in cell movement and morphogenesis (2003, background): “To move, the cell generates traction through contractile actin bundles pulling on focal contacts attached to the substrate, which must be assembled at the cell front and disassembled at the cell rea”
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly (2004, background): “Cell migration is an integrated process that requires the coordinated regulation of various signalling molecules, including some kinases and phosphatase”
Focal adhesion kinase: the first ten years (2003, background): “These observations argue that FAK is a critical component of a pathway leading to signals that either positively or negatively modulate the assembly and breakdown of adhesions at the leading and/or trailing edges of migrating cells (Webb et al., 2002).”
Regulation of cadherin-mediated adhesion in morphogenesis (2005, background): “The actin cytoskeleton is closely associated with cadherin-mediated cell adhesion, especially at the adherens junction, similar to the linkage of integrins to actin at focal adhesion”
Calpain-mediated proteolysis of talin regulates adhesion dynamics (2004, background): “Because of this involvement in cell motility, adhesions are necessarily dynamic structures that undergo repeated cycles of formation and disassembl”
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase (2005, background): “Focal adhesions contain clustered integrins and numerous cytoplasmic proteins, such as FAK, talin, vinculin, paxillin and zyxin, that contribute to integrin connection to the actin cytoskeleton and signal transductio”
Adhesion signaling – crosstalk between integrins, Src and Rho (2009, background): “In addition to regulating protein-protein interactions and thereby augmenting cell-matrix adhesion turnover (Webb et al., 2002), downstream of integrins SFKs control guanine-exchange factors (GEFs) and GTPase-activating proteins (GAPs) that act on Rho-GTPases (Fig.”
Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “Processes coupled to adhesion dynamics The formation and disassembly of the different types of adhesions have been studied mainly in 2D culture systems using spreading or migrating fibroblasts or fibroblast-like cells plated on fibronectin, collagen or other purified ECM protein”