Adhesion signaling – crosstalk between integrins, Src and Rho

By S. Huveneers, E. Danen. Journal of Cell Science, 2009

874 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dfc92dd179eefe0ad629ed9239c5c969b66f58ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. C. Carraher
2. Purva Singh
3. E. Mojares
4. Cameron G Walker
5. J. Schwarzbauer
6. Clare M. Waterman
7. Armando E. del Río Hernández

In Immunology and Allergy

1. C. Carraher
2. Purva Singh
3. E. Mojares
4. Cameron G Walker
5. J. Schwarzbauer
6. Clare M. Waterman
7. Armando E. del Río Hernández

In Molecular Biology

1. David R. Sibley
2. Huanhuan Chen
3. Li-li Zheng
4. Zhenling Liu
5. Li-Ping Sun
6. Lei Shi
7. C. Cheng
8. Mary M. Wohlford

Citations in the corpus

• Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “ECM signalling is a crucial cellular process that drives cell proliferation, differentiation, and defers apoptosis [147].”
• Linking actin dynamics and gene transcription to drive cellular motile functions (2010, neutral): “Integrin-mediated actin dynamics is primarily achieved by activating the RHOA and RAC1 GTPases, which involves the regulation of Rho GEFs by the kinases integrin-linked kinase ( ILK ), focal adhesion kinase ( FAK ) and SRC”
• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “Under the mediation of soluble ligands, extracellular matrix (ECM), or cell surface bound ligands including growth factors, proteases, cytokines, structural constituents of the ECM (like collagen and fibronectin), plasma proteins, microbial pathogens, or receptors specific to immune cells, integrin ”
• Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “The Rho/mDia pathway, in turn, likely regulates FA turnover by localizing c-Src to mature FAs (Yamana et al. 2006; for a review see Huveneers & Danen 2009).”
• The Blood-Testis Barrier and Its Implications for Male Contraception (2012, background): “Src kinases are also involved in embryonic development, cell growth, cell movement, and actin-cytoskeletal dynamics and, similar to FAK, are central to integrin-based signaling, most notably, at the focal adhesion complex at the cell-matrix interface (Huveneers and Danen, 2009; Guarino, 2010; Tegtme”
• Assembly of Fibronectin Extracellular Matrix (2010, background): “For example, members of the Src kinase family work with FAK in many cell types (Mitra & Schlaepfer 2006); assembly is delayed but not ablated in cells lacking these kinases (Wierzbicka-Patynowski & Schwarzbauer 2002) and is reduced in cells with enhanced Src activity (Huveneers & Danen 2009).”