Intravital imaging of cell movement in tumours

By J. Condeelis, J. Segall. Nature Reviews. Cancer, 2003

973 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biophysics, Cell Biology

View Paper: https://www.semanticscholar.org/paper/61dbe31c0c3d8a7efdb35ea0f30530d13a2a610d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Pengfei Lu
2. J. Pollard
3. J. Condeelis
4. J. Erler
5. T. Cox
6. J. Joyce
7. A. Rajasekaran
8. J. Christiansen

In Biophysics

1. Pengfei Lu
2. J. Pollard
3. T. Cox
4. J. Erler
5. A. Rajasekaran
6. J. Christiansen
7. J. Condeelis
8. Erik Sahai

In Cell Biology

1. Pengfei Lu
2. J. Pollard
3. J. Erler
4. T. Cox
5. A. Rajasekaran
6. J. Christiansen
7. J. Condeelis
8. Valerie M. Weaver

Citations in the corpus

• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. (2006, methodology): “(Adapted from Lin et al., 2002; Condeelis and Segall, 2003.)”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “Once the tumor cells break away from the constraint of ECM networks, they would move toward the stimuli along with the ECM fiber by interacting with other ECM components, such as fibronectin and vitronectin [90, 91].”
• Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “To address these concerns, second harmonic generation using two-photon microscopy has been used in live animals to monitor how epithelial and stromal cells interact with and initiate collagen remodeling to regulate its architecture [36,39,49,78,89,101].”
• TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “The development of novel imaging techniques has illuminated the processes of tumor cell movement which leads to metastasis [49,50].”
• Fluorescence molecular imaging. (2006, background): “5–3 microns) at depths of several hundred microns under the surface (16, 18, 59).”
• Chemotaxis in cancer (2011, background): “The cofilin activity cycle in tumour cells begins in lamellipodia with the local activation of cofilin by PLCγ1-dependent hydrolysis of PI(4,5)P2 and in invadopodia with the SRC-initiated Abelson-related gene (ARG; also known as ABL2) kinase-dependent tyrosine phosphorylation of CTTN79,86,89 (FIG.”
• Extracellular matrix: a dynamic niche component during cancer progression (2012, positive): “…matrix in cancer progression • Lu et al. they are often found in areas where active tissue invasion and tumor vasculature are observed (Condeelis and Segall, 2003; Provenzano et al., 2006; Levental et al., 2009), suggesting that they play an active role in facilitating cancer cell…”
• Molecular mechanisms of invadopodium formation (2005, neutral): “In tumors, invadopodia-like structures are believed to be important for tumor cells to penetrate the basement membrane of blood vessels (Condeelis and Segall, 2003).”
• Matrix metalloproteinases and tumor metastasis (2006, background): “Visualization of intravasation became possible through the development of multiphoton microscopy which allows for intravital imaging of tumor cell intravasation on a single cell level in real time [143, 144].”
• Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “In cancer lesions and tumor xenografts monitored by 3D intravital microscopy, these interfaces are often used by invading cells with little sign of structural alteration or degeneration (Alexander et al., 2008; Condeelis and Segall, 2003).”
• The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “Because it is now possible to visualize the movement and morphology of individual tumor cells in real-time in a living animal (Condeelis and Segall, 2003), the examination of EMT in real-time is a possibility for the future.”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Whereas solitary movement of tumor cells in vivo, particularly in cooperation with macrophages, directs tumor cells to the blood vessels resulting in hematogenous dissemination [83, 84], collectively migrating cells have been reported to result in lymphatic dissemination [82].”
• TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. (2005, background): “The role of epithelial plasticity in normal embryogenesis and in carcinoma invasiveness and metastasis is a topic of intense current research (Condeelis and Segall, 2003; Grünert et al., 2003).”