Cell adhesion: integrating cytoskeletal dynamics and cellular tension
By J. Parsons, A. Horwitz, M. Schwartz. Nature reviews. Molecular cell biology, 2010
2,000 citations recorded by the source corpus.
Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. For most cells in most environments, movement begins with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the substratum, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.
Subfields: Cell Biology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/b38282d4b18e3b536f13d22cf2631796619265b5
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Citations in the corpus
- The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “Focal adhesions formed on 2D substrates are typically 1–10 μm in size, much larger than the fibre diameter of the EC”
- FAK promotes recruitment of talin to nascent adhesions to control cell motility (2012, background): “Integrin-based adhesion assembly and turnover are highly dynamic events underlying cell movement (Parsons et al., 2010).”
- E-cadherin–integrin crosstalk in cancer invasion and metastasis (2013, background): “These two kinases are pivotal in regulating crosstalk between the two adhesion types by controlling actomyosin contractility and thus adhesive strength, which impacts on the collective migration of cells (Friedl and Gilmour, 2009; Parsons et al., 2010).”
- Recent advance in surface modification for regulating cell adhesion and behaviors (2020, background): “Cell adhesion is also associated with a range of pathological diseases [11], such as arthritis, cancer, os-”
- Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. (2012, background): “FAs are complex intracellular linkages between integrins and the F-actin cytoskeleton, which function as a mechanical force transducer and a signaling module (Parsons et al. 2010).”
- The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. (2014, background): “They are continuously interactingwith other cellular structures and receiving signals, directing contacts and sending instructions, maintaining cellular polarity andmechanical properties,while undergoing constant turnover of their constituents [144,146,148–150].”
- Actin stress fibers – assembly, dynamics and biological roles (2012, background): “Focal adhesions are often connected to actin stress fibers, which thus appear to play an important role in cell adhesion and migration (Geiger et al., 2009; Parsons et al., 2010).”