Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration.

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One-dimensional topography underlies three-dimensional fibrillar cell migration (2009, background): “Additional contrasts to 2D migration include a dependence on myosin II contractility for rapid migration with a requirement for an anterior microtubule (MT) bundle for both 1D and 3D forms of ECM-directed migration.”
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner (2008, neutral): “Recent evidence suggests that adhesions form at the base of the lamellipodiu”
The many faces of actin: matching assembly factors with cellular structures (2007, background): “Although these properties were revealed by Abercrombie's landmark studies, subsequent work better defined additional adhesive differences, with lamellipodia being weakly adherent, and strong adhesion beginning at the lamellipodia–lamella boundar”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “Feedback from mechanical and biochemical signals within FAs and the F-actin cytoskeleton coordinates the behaviors of the protrusive and contractile modules by promoting and sustaining the proper spatial and temporal control.”