Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

By Ellen J. Ezratty, M. Partridge, G. Gundersen. Nature Cell Biology, 2005

655 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/7a1115a47571b5466f3c61c3962cfb222f54af11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Humphries
2. M. Schaller
3. Clare M. Waterman
4. Y. Yarden
5. David S. Harburger
6. D. Calderwood

In Immunology and Allergy

1. M. Humphries
2. M. Schaller
3. Clare M. Waterman
4. D. Calderwood
5. David S. Harburger

Citations in the corpus

• Synergistic control of cell adhesion by integrins and syndecans (2007, background): “Microtubule-directed disassembly of FAs is blocked by the inhibition of FAK or dynamin activity, and recruitment of dynamin to FAs depends on the association between dynamin and activated FA”
• Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions (2010, background): “Phosphorylation of tyrosine 925 and the subsequent recruitment of Grb2 and dynamin into a complex with FAK are required for microtubule-induced disassembly of focal adhesions (Ezratty et al., 2005).”
• Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “Finally, some evidence suggests that FAK regulates the dynamin- mediated endocytosis of integrins (Ezratty et al. 2005).”
• The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “This would contrast cadherin adhesions to integrin-containing focal adhesions because microtubule association with focal adhesions triggers their disassembly ( Ezratty et al., 2005 ).”
• Derailed endocytosis: an emerging feature of cancer (2008, background): “Because earlier studies noted that growing microtubules contact focal adhesions transiently, thereby inducing their disassembly, Ellen Ezratty and her colleagues exposed resting cells to nocodazole, a microtubule-severing agent, and studied the wave of microtubule regrowth that follows nocodazole re”
• HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, neutral): “This signaling cascade may also influence reestablishment of focal adhesions at and following cytokinesis, given the growing appreciation of the role of microtubules in guiding the formation of these structures (Ezratty et al., 2005; Strickland et al., 2005).”
• Methods for Improving Brain-Computer Interface: Using A Brain-Directed Adjuvant and A Second-Generation Artificial Intelligence System to Enhance Information Streaming and Effectiveness of Stimuli (2023, unknown): “MTs are involved in cell mitosis and meiosis [25, 26].”