Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering

By Junmin Zhu. Biomaterials, 2010

1,347 citations recorded by the source corpus.

In this review, we explore different approaches for introducing bioactivity into poly(ethylene glycol) (PEG) hydrogels. Hydrogels are excellent scaffolding materials for repairing and regenerating a variety of tissues because they can provide a highly swollen three-dimensional (3D) environment similar to soft tissues. Synthetic hydrogels like PEG-based hydrogels have advantages over natural hydrogels, such as the ability for photopolymerization, adjustable mechanical properties, and easy control of scaffold architecture and chemical compositions. However, PEG hydrogels alone cannot provide an ideal environment to support cell adhesion and tissue formation due to their bio-inert nature. The natural extracellular matrix (ECM) has been an attractive model for the design and fabrication of bioactive scaffolds for tissue engineering. ECM-mimetic modification of PEG hydrogels has emerged as an important strategy to modulate specific cellular responses. To tether ECM-derived bioactive molecules (BMs) to PEG hydrogels, various strategies have been developed for the incorporation of key ECM biofunctions, such as specific cell adhesion, proteolytic degradation, and signal molecule-binding. A number of cell types have been immobilized on bioactive PEG hydrogels to provide fundamental knowledge of cell/scaffold interactions. This review addresses the recent progress in material designs and fabrication approaches leading to the development of bioactive hydrogels as tissue engineering scaffolds.

Subfields: Biomaterials, Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/0cb2aa01decb30cccea3d489c056074fbada6fd1

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In Biomaterials

1. R. Marchant
2. Sigrid A. Langhans
3. A. Panwar
4. L. P. Tan
5. V. Shukla
6. J. Maitra
7. Junmin Zhu

In Biomedical Engineering

1. R. Marchant
2. Sigrid A. Langhans
3. V. Shukla
4. J. Maitra
5. A. Panwar
6. L. P. Tan
7. Junmin Zhu

In Molecular Medicine

1. R. Marchant
2. Sigrid A. Langhans
3. V. Shukla
4. J. Maitra
5. A. Panwar
6. L. P. Tan
7. Junmin Zhu

Citations in the corpus

• Hydrogels: Properties and Applications in Biomedicine (2022, background): “These PVA and PEG hydrogels are widely used for the 3D scaffold due to its biocompatibility (adaptability and nontoxicity for living tissue), absence of immunogenicity, and adjustable stiffness [164,165].”
• Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “PEG gels and their derivatives have been used in a variety of 3D cell culture applications including stem cell differentiation, cell invasion and angiogenesis (Lutolf et al., 2003; Moon et al., 2010; Zhu, 2010; Caiazzo et al., 2016).”
• A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds (2021, background): “Polymerization, interlinkage, and functionality (changed by block structures, by combining them, by copolymerization) of their molecular weight, molecular structure, physical and chemical features make them easily synthesized as compared to naturally occurring polymers [83,84].”
• Cross-linking in Hydrogels - A Review (2014, background): “Some other crosslinking compounds are formaldehyde, epoxy compounds, dialdehyde [34, 35, 36].”