Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion

By Shelly R. Peyton, A. Putnam. Journal of Cellular Physiology, 2005

678 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/aa96cd6e10dd8377576e561472b396d1fddcfaf6

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Citations in the corpus

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression (2010, background): “Numerous studies link the Rho/ROCK pathway to matrix stiffness responses (Paszek et al., 2005; Peyton and Putnam, 2005; Assoian and Klein, 2008), although none have examined the interrelationship of stiffness, Rho/ROCK, and prostaglandin signaling.”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “, 2007), (2) changes in Rho activity (Peyton and Putnam, 2005), and (3) stretch activated calcium channels (Lo et al.”
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. (2006, methodology): “The dose of Y27632 used in this study has been shown to profoundly (and optimally) alter cell shape and cytoskeletal morphology (54), whole cell prestress (56), cell migration speed ( 55 ), and focal adhesion size and turnover (76) in multiple cell types, including endothelial cells (76).”
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating (2008, background): “The elasticity ( E ) of ECM is an ‘insoluble cue’ for many cells, influencing cell shape, protein expression and organization, as well as differentiation (Discher et al., 2005; Pelham and Wang, 1997; Peyton and Putnam, 2005).”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, background): “the relationship depending strongly on cell type, degree of adhesion, and other factors (15, 25).”
Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, background): “Motility of cultured myocytes also depends on substrate stiffness, with a maximal rate of motility found at intermediate stiffness between 21 kPa and 52 kPa depending on the density of adhesive ligand (16).”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “The migration rate of many cell types is optimized at intermediate levels of adhesion, and modulating the density or mechanical compliance of the ECM alters migration speed in a biphasic fashion (Gaudet et al. 2003, Lo et al. 2000, Palecek et al. 1997, Pelham & Wang 1997, Peyton & Putnam 2005).”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, positive): “It is now readily accepted that the mechanics of substrates impact the phenotype of cells cultured on them, and may induce changes in proliferation [76], motility [77], or differentiation [78].”
Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds (2011, background): “…pore size, pore shape, interconnectivity, specific surface area) (O'Brien & Gibson, 2005b) and mechanical properties (Engler & Discher, 2006; Peyton & Putnam, 2005) have been shown to significantly influence cell behaviors such as adhesion, growth and differentiation, and to affect the…”