Integrin signalling during tumour progression

By Wenjun Guo, F. Giancotti. Nature reviews. Molecular cell biology, 2004

1,571 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5c2ae0f05cfd6630f6b130e12b1ac6c8269d661d

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Citations in the corpus

Protein-tyrosine phosphatases and cancer (2006, background): “The importance of both integrin-mediated adhesion and motility, as well as adhesion mediated by cell–cell adhesion molecules in cancer progression has been recently reviewe”
Tumor metastasis: mechanistic insights and clinical challenges (2006, background): “Each heterodimer binds to specific proteins in the ECM and can transmit signals into or out of the cel”
Latent bone metastasis in breast cancer tied to Src-dependent survival signals (2009, background): “The mechanism for Src activation in ER breast cancer cells remains unknown but could involve receptor tyrosine kinases, G protein-coupled receptors, integrins, and focal adhesion kinase (Bromann et al., 2004; Guo and Giancotti, 2004; Ishizawar and Parsons, 2004; Mitra and Schlaepfer, 2006).”
Anoikis: an emerging hallmark in health and diseases (2012, neutral): “The role of ECM as anoikis suppressor is well established [1,49] and several integrins (α1β1, α2β1, α3β1, α5β1, α6β1, α6β4, αvβ3) have a profound impact on cell survival [2,44,50] in both normal or neoplastic cells [2,51,52].”
Integrins in cancer: biological implications and therapeutic opportunities (2010, neutral): “The role of integrins in cell migration and invasion is one of their most studied functions in tumour biology and has recently been reviewed elsewher”
New signals from the invasive front (2006, background): “Importantly, binding to these ECM components activates integrins, which, in turn, induce intracellular signalling cascades that modulate cell proliferation, survival, polarity, motility and differentiatio”
Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation (2010, background): “Integrins have distinct roles and are critical mediators and regulators in the physiological and pathological angiogenesis, including tumor angiogenesis, by activating kinases [68].”
Cancer metastasis: building a framework. (2006, background): “In particular, the α6β4 integrin, which binds to the extracellular matrix protein laminin, forms signaling complexes with oncogenic receptor tyrosine kinases, including Met, EGFR, and Her2 (Guo and Giancotti, 2004). αVβ3 and α3β1 integrins have also been implicated in later stages of metastasis, spe”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, background): “In the absence of such anchorage, epithelial cells normally undergo anoikis, a form of apoptosis triggered by loss of anchorage to substratum (Guo and Giancotti, 2004).”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “Building on the notion of integrin-specific signaling, we made the hypothesis that certain integrins promote tumorigenesis, while others do not exert this effect or they may even suppress tumorigenesis (Guo and Giancotti, 2004).”
The signaling mechanism of ROS in tumor progression (2007, background): “signal for survival and invasion of tumor cells such as malignant melanoma [54, 55].”
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions (2017, background): “PDT induced damage to structural proteins such as integrins could disrupt essential stromal-tumor signalling [48].”
Tensional homeostasis and the malignant phenotype. (2005, background): “Indeed, integrin levels and signaling are altered in " stiff " tumors (Guo and Giancotti, 2004), and integrins and Rho GTPases can modify the tumorigenic behavior of a tissue (Liu et al., 2004; White et al., 2004).”