Regulation of cadherin-mediated adhesion in morphogenesis

By B. Gumbiner. Nature reviews. Molecular cell biology, 2005

1,577 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/97b1a052df0a829a4012ee00537d44450a2397cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. W. Nelson
2. Jennifer M. Halbleib
3. E. Dejana
4. C. Niessen
5. B. Hinz
6. D. Kufe
7. F. Orsenigo
8. Donald E. Ingber

In Molecular Biology

1. C. Niessen
2. W. Nelson
3. E. Dejana
4. R. Weinberg
5. Jennifer M. Halbleib
6. F. Orsenigo
7. B. Hinz
8. D. Kufe

Citations in the corpus

• The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “Cadherins are transmembrane proteins whose homotypic interaction between neighboring cells creates adherens junctions (Gumbiner, 2005).”
• Mechanical control of tissue and organ development (2010, background): “…with the surface expression level of cadherin cellcell adhesion receptors in cultured cells (Foty and Steinberg, 2005), which are also crucial for progenitor cell sorting into distinct germ layers, both in vitro (Schotz et al., 2008) and during vertebrate gastrulation in vivo (Gumbiner, 2005).”
• Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “Cadherins link to the cytoskeleton by forming junctional complexes that contain β-catenin and γ-catenin, which bind actin filaments and intermediate filaments, respectivel”
• Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 (2008, background): “Cell–cell junctions can also act as signalling structures that communicate cell position, limit growth and apoptosis and, in general, regulate vascular homeostasi”
• Tensile forces govern germ-layer organization in zebrafish (2008, positive): “Cadherin adhesion molecules, particularly E-cadherin, are known to have key roles in tissue morphogenesis during vertebrate gastrulatio”
• Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “Gumbiner BM. (2005). Regulation of cadherin-mediated adhesion in”
• From cells to organs: building polarized tissue (2008, background): “Cells can also communicate with other cells through an array of adhesion molecules, such as cadherin”
• E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components (2011, background): “Cadherins are key regulators of embryonic development and adult tissue homeostasis (5).”
• Cadherin switching (2008, background): “Likewise, when epithelial cells change their relative positions within a tissue, they become motile cells, their cell-cell junctions are disrupted and the actin cytoskeleton is reorganized (Boyer et al., 2000; Gumbiner, 2005; Keller, 2002; Savagner, 2001).”
• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010, background): “CDH1 encodes the epithelial cell adhesion molecule E-cadherin, a transmembrane glycoprotein that forms the core of adherens junctions between adjacent epithelial cell”
• Membrane fluctuations mediate lateral interaction between cadherin bonds (2017, background): “This selectivity is promoted by small variations in the two-dimensional binding affinity (2D-Ka) for trans-dimerization [3, 9], which allows proteins of the cadherin family to have a structural and regulatory role in tissue morphogenesis, homoeostasis [10] and malignancy: E-cadherins in particular s”
• Tight junctions/adherens junctions: basic structure and function. (2007, background): “If cadherins can mediate heterophilic adhesion and what the exact molecular requirements of the EC domain for adhesion are, are both subjects of an ongoing debate (reviewed in Gumbiner, 2005).”
• Mucins in cancer: function, prognosis and therapy (2009, background): “Adherens junctions maintain epithelial morphogenesis and largely consist of cadherin complexes that participate in interactions between epithelial cell”
• The role of adherens junctions and VE-cadherin in the control of vascular permeability (2008, background): “VE-cadherin is represented as a dimer, which is the minimal functional unit of cadherins; see Gumbiner (Gumbiner, 2005), in which various models of the intercellular association of cadherin dimers are discussed.”