The neutrophil NADPH oxidase.

By B. Babior, J. Lambeth, W. Nauseef. Archives of Biochemistry and Biophysics, 2002

874 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5c4336254ff9718d840890ffde096b4933dcca11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Neurology

Citations in the corpus

Hydrogen peroxide as second messenger in lymphocyte activation (2002, background): “The most relevant enzyme for the inducible production of ROS during signal transduction is the leukocyte NADPH oxidase (also known as respiratory burst oxidase”
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “Superoxide production in neutrophils results from membrane assembly and activation of NADPH oxidase, which is a multicomponent enzyme complex for electron transfer leading to one-electron reduction of molecular oxygen (Babior et al., 2002).”
Oxidative stress in the placenta (2004, background): “The enzyme NADPH oxidase is capable of generating large amounts of ROS in neutrophils, macrophages, and monocytes (Babior et al. 2002).”
Myeloperoxidase: friend and foe (2005, neutral): “[76–79]).”
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “The prototypic neutrophil NADPH oxidase comprises a membrane-associated low-potential cytochrome b558 composed of one p22 and one gp91 subunit and several cytosolic regulatory subunits (p47, p40, p67, and the small G protein Rac1 or Rac2) that translocate to the membrane and associate with the cytoc”
Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification (2002, background): “Following stimulation, these cells undergo a respiratory burst characterized by a 20-fold increase in oxygen consumption, which is accompanied by an increase in glucose utilization and production of reduced nicotinamide phosphate dinucleotide (NADPH) by the pentose phosphate pathway (14).”
Reactive oxygen species in vascular biology: implications in hypertension (2004, positive): “(phox for PHagocyte OXidase), p47phox, p67phox, p40phox, p22phox, and gp91phox (Babior et al. 2002; Vignais 2002).”
Mitochondrial formation of reactive oxygen species (2003, background): “Enzymatic sources include NADPH oxidases located on the cell membrane of polymorphonuclear cells, macrophages and endothelial cells (Babior, 2000; Vignais, 2002; Babior et al. 2002) and cytochrome P450-dependent oxygenases (Coon et al. 1992).”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “work of Bernard Babior [198], showed that active immune cells produce O2 via NOX isoforms (principally NOX2 [23]).”
NOX enzymes and the biology of reactive oxygen (2004, background): “Until recently, the single example of 'deliberate' generation of ROS in mammalian cells was the NOX of phagocytes (Phox) (mainly neutrophils and macrophages) that catalyses the RESPIRATORY BURST”
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies (2004, background): “The essential components of the NADPH phagocyte oxidase complex are two membrane proteins, gp91-phox and p22-phox, and three cytosolic proteins, p47-phox, p67-phox and Rac (reviewed in Ref”
Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, background): “As might be expected from the cytotoxicity of superoxide, the leukocyte enzyme is inactive in the absence of stimulation (6, 8).”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “The ROS produced by these enzymes has an essential function in neutrophils and macrophages as a mechanism for effective bacterial killing and host defense (51, 52).”
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “These cells express very large amounts of gp91phox, now also called Nox2, along with its regulatory subunits p47phox, p67phox, p40phox and Rac2, reviewed in [1,2].”