Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.

By J. Lambeth. Free Radical Biology & Medicine, 2007

661 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/19f8d22ac515dc1493053c90e5d30964739b8c56

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Citations in the corpus

Targeting Free Radicals in Oxidative Stress-Related Human Diseases. (2017, background): “Considering the complexity and biological specificity of each individual involved in an epidemiological study, wemay ask at least two important questions – is there a unifying feature that determines the impact of the factors listed above?Why is it that the results are often inconsistent, even withi”
Mitochondrial Energetics and Therapeutics (2010, positive): “Hence, ROS from both the Nox/Doux proteins and the mitochondria may contribute to age-related diseases (193).”
NADPH Oxidase-4 Mediates Myofibroblast Activation and Fibrogenic Responses to Lung Injury (2009, background): “Furthermore, NOX-4 activation in myofibroblasts and tissue fibrogenesis may represent yet another example of antagonistic pleiotropy, whereby genes that confer a survival advantage during early reproductive life mediate potential harmful effects in later lif”
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, positive): “Besides the mETC, low levels of ROS are produced by membrane-localized NADPH oxidase (Nox) enzymes (65), peroxisomes (100), and the cytochrome p450 system (43).”
Nitric oxide and redox mechanisms in the immune response (2011, background): “NOX is also stimulated by treatment with agents that activate calcium entry or by treatment with cellular products such as arachidonic acid [34–36].”
Oxygen Toxicity and Reactive Oxygen Species: The Devil Is in the Details (2009, background): “However, the role of reactive oxygen species (ROS) in biologic systems is entirely dependent on context: location, neighbors, and timing (2).”
Two ways to survive an infection: what resistance and tolerance can teach us about treatments for infectious diseases (2008, background): “For example, reactive oxygen species that are produced during an immune response are important for fighting infections, but their activity can also induce severe immunopathology and even death in some cases, thereby decreasing toleranc”