NOX enzymes and the biology of reactive oxygen

By J. Lambeth. Nature reviews. Immunology, 2004

3,105 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bbe46d4075ba4fd4344d614753a6a6b65e3c15e5

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Citations in the corpus

ROS Function in Redox Signaling and Oxidative Stress (2014, background): “H2O2 is generated from superoxide produced by mitochondria and NADPH oxidases [8,9].”
Abiotic and Biotic Stress Response Crosstalk in Plants (2011, background): “The NADPH oxidase is a multicomponent complex known as respiratory burst oxidase (RBO), initially described in mammals (Lambeth, 2004).”
ROS and ROS-Mediated Cellular Signaling (2016, background): “NADPH oxidases (Nox) including Nox1 to Nox5 and Duox1 and Duox2, which are classified into three groups, according to the presence of domains in addition to the gp91phox (NOX2) domain, are another important source of cellular ROS [17, 18]: NOX1, NOX3, and NOX4 are similar in size and domain structur”
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets (2011, background): “NOX2 oxidase in phagocytic cells was the first member of the NADPH oxidase family to be identifie”
Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. (2005, background): “and many functional responses [81].”
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. (2008, background): “The prototypical Nox is the phagocyte NADPH oxidase that is normally quiescent but generates a large amount of (O2 ) upon activation during phagocytosis via the one electron-reduction of oxygen by NADPH, which participate in host defense by killing invading microbes [59,61].”
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control (2006, neutral): “It is important to emphasize that oxidation and reduction of disulfide”
Mitochondria in innate immune responses (2011, background): “Phagocytosis is associated with the production of ROS via the respiratory burst , a necessary effector response for the destruction of intracellular microorganism”
13 reasons why the brain is susceptible to oxidative stress (2018, methodology): “use prosthetic redox groups to oxidise NADPH to reduce O2 to O2 [22,23].”
Functions of the respiratory burst oxidase in biotic interactions, abiotic stress and development. (2005, background): “In phagocytes, these regulatory proteins include the p47, p67 and p40 phosphoproteins and Rac2, a small GTP-binding protein [11,12].”
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. (2007, background): “NOX1–NOX3 require the presence of p22 on the membrane and are more or less dependent on cytoplasmic subunits p47, p67, and p40, which translocate to the membrane and form with NOX and p22 an active holoenzyme complex in response to cell stimulation (4, 32).”
Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “The nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are a group of plasma membrane-associated enzymes found in a variety of cell types [28].”
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, neutral): “…oxidase - derived ROS , such as H 2 O 2 , have been pro - posed to play a role in local cell signaling by affecting the function of various kinases , phosphatases , phospholipases , and transcrip - tion factors , at low submicromolar concentrations ( Lambeth , 2004 ; Bedard and Krause , 2007 ) .”