Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

By F. Fang. Nature Reviews Microbiology, 2004

1,636 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/2c7c1623e2b5d7cdbf403995895cc26c763877ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Arturo Zychlinsky
2. V. Brinkmann
3. C. Winterbourn
4. Eric G. Pamer
5. M. Hampton
6. C. Goosmann
7. A. Kettle
8. T. Fuchs

In Microbiology

1. Arturo Zychlinsky
2. V. Brinkmann
3. Stefan H. E. Kaufmann
4. G. Weiss
5. Barry Halliwell
6. James J. Collins
7. David B. Graves
8. Michael Lesser

Citations in the corpus

• Reactive Oxygen Species and Neutrophil Function. (2016, background): “If nitric oxide were generated concurrently, it would be expected to react rapidly with superoxide to give peroxynitrite, which is both a strong oxidant and microbicidal (72).”
• Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life (2006, background): “ROS production in animals by phagocytes and by other cells in the gastrointestinal and respiratory tracts is a defense against microorganisms (Fang, 2004; Donko et al., 2005).”
• Macrophage defense mechanisms against intracellular bacteria (2015, background): “Part of the anti-mycobacterial activity of cathelicidin can be traced back to augmentation of NOX2-mediated ROI formation and modulation of cytokine expression (84) as well as to induction of autophagy (4, 85).”
• Myeloperoxidase: friend and foe (2005, neutral): “[345–347]).”
• The microbial nitrogen-cycling network (2018, background): “Nitric oxide is a signaling molecule, a toxin 90 and an intermediate of the denitrification, nitrification and anammox processes.”
• Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, background): “The activity of the inducible nitric oxide synthase, or NOS2 , the isoform most relevant to phagocyte”
• Novel cell death program leads to neutrophil extracellular traps (2007, positive): “These data further support our fi nding that NADPH oxidase is essential not only for phagosomal killing (Fang, 2004; Segal, 2005) but also for NET formation.”
• Mycobacterium tuberculosis: Success through dormancy (2012, background): “ROS and RNS generated by the phagosomal enzymes NADPH phagocyte oxidase and inducible nitric oxide synthase (iNOS) damage captured microorganisms by modification of their DNA, lipids, thiols, tyrosine side chains, and active centers of metal-dependent proteins (Fang, 2004).”
• Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “Space limitations preclude coverage here, and for information on production of nitric oxide and its antimicrobial and inflammatory actions readers are referred to other review”
• Oxidative stress in marine environments: biochemistry and physiological ecology. (2006, background): “REACTIVE NITROGEN SPECIES Many cells also produce nitric oxide, or nitrogen monoxide (NO•), a molecule implicated initially in neurotransmission but now a known participant in diverse processes involving oxidative stress (13).”
• Monocyte-mediated defense against microbial pathogens. (2008, background): “Monocytes kill bacteria by producing reactive nitrogen intermediates (RNIs) and reactive oxygen intermediates (ROIs) (90) and through the action of phagolysosomal enzymes (91).”
• The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology (2012, background): “There is evidence that RONS act synergistically with each other and/or with other antimicrobial systems so pathogens have difficulty in avoiding their combined effects [86].”