Oxidative stress in the placenta

By L. Myatt, X. Cui. Histochemistry and Cell Biology, 2004

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Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. (2011, background): “Moreover, oxidative stress in the placenta is known to cause placental dysfunction and to induce pregnancy complication”
Benefits and costs of parental care (2012, background): “4 Oxidative stress The cost of parental care in terms of oxidative stress is supported by correlative evidence, mostly in mammals (e.g. Upreti and Misro 2002; Myatt and Cui 2004), but also by some experiments on birds.”
The Challenges of Integrating Oxidative Stress into Life-History Biology (2011, background): “Second, although there is no doubt that redox reactions and signaling occur during female reproduction (e.g., Myatt and Cui 2004, Agarwal et al. 2005), it is less clear whether greater reproductive effort imposes a direct cost in terms of risk of accumulating oxidative damage.”
The effects of oxidative stress on female reproduction: a review (2012, background): “Importantly, OS during the 2 trimester of pregnancy is considered a normal occurrence, and is supported by mitochondrial production of lipid peroxides, free radicals, and vitamin E in the placenta that increases as gestation progresses [66-69].”